Making the Cut: the Chemical Biology of Cytokinesis

Overview

Journal ACS Chem Biol

Publisher American Chemical Society

Specialties Biochemistry
Biology

Date 2009 Dec 18

PMID 20014865

Citations 26

Authors

G Ekin Atilla-Gokcumen

Adam B Castoreno

Sofia Sasse

Ulrike S Eggert

Affiliations

Soon will be listed here.

Abstract

Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.

Citing Articles

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Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive Model for Assessing Neurotoxicity of Contaminants.

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A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis.

Gill M, Jarman P, Hearnden V, Fairbanks S, Bassetto M, Maib H Angew Chem Int Ed Engl. 2022; 61(27):e202117449.

PMID: 35416386 PMC: 9323417. DOI: 10.1002/anie.202117449.

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