Optical Imaging of Mammary and Prostate Tumors in Living Animals Using a Synthetic Near Infrared Zinc(II)-dipicolylamine Probe for Anionic Cell Surfaces

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2009 Dec 18

PMID 20014845

Citations 51

Authors

Bryan A Smith

Walter J Akers

W Matthew Leevy

Andrew J Lampkins

Shuzhang Xiao

William Wolter

Mark A Suckow

Samuel Achilefu

Bradley D Smith

Affiliations

Soon will be listed here.

Abstract

In vivo optical imaging shows that a fluorescent imaging probe, comprised of a near-infrared fluorophore attached to an affinity group containing two zinc(II)-dipicolylamine (Zn-DPA) units, targets prostate and mammary tumors in two different xenograft animal models. The tumor selectivity is absent with control fluorophores whose structures do not have appended Zn-DPA targeting ligands. Ex vivo biodistribution and histological analyses indicate that the probe is targeting the necrotic regions of the tumors, which is consistent with in vitro microscopy showing selective targeting of the anionic membrane surfaces of dead and dying cells.

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