» Articles » PMID: 20010069

Comparison of Interferon Gamma and Interferon Gamma-inducible Protein-10 Secretion in HIV-tuberculosis Patients

Overview
Journal AIDS
Date 2009 Dec 17
PMID 20010069
Citations 24
Authors
Affiliations
Soon will be listed here.
Abstract

Interferon gamma (IFNgamma)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNgamma and IFNgamma-inducible protein-10 levels in culture of whole blood samples from HIV-TB patients. We report that IFNgamma-inducible protein-10 detects a greater number of HIV-TB cases than IFNgamma and suggest that IFNgamma-inducible protein-10 may be a better alternative marker for latent TB infection diagnosis among immunocompromised individuals.

Citing Articles

Performance of T-Track TB, a Novel Dual Marker RT-qPCR-Based Whole-Blood Test for Improved Detection of Active Tuberculosis.

Meier J, Mobus S, Heigl F, Asbach-Nitzsche A, Niller H, Plentz A Diagnostics (Basel). 2023; 13(4).

PMID: 36832246 PMC: 9955725. DOI: 10.3390/diagnostics13040758.


HIV-Infected Patients Developing Tuberculosis Disease Show Early Changes in the Immune Response to Novel Antigens.

Meier N, Battegay M, Ottenhoff T, Furrer H, Nemeth J, Ritz N Front Immunol. 2021; 12:620622.

PMID: 33777000 PMC: 7994263. DOI: 10.3389/fimmu.2021.620622.


Diagnostic Accuracy of Interferon Gamma-Induced Protein 10 mRNA Release Assay for Tuberculosis.

Blauenfeldt T, Villar-Hernandez R, Garcia-Garcia E, Latorre I, Holm L, Muriel-Moreno B J Clin Microbiol. 2020; 58(10).

PMID: 32719030 PMC: 7512164. DOI: 10.1128/JCM.00848-20.


Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis.

Qiu X, Tang Y, Zou R, Zeng Y, Yue Y, Li W Sci Rep. 2019; 9(1):11408.

PMID: 31388072 PMC: 6684649. DOI: 10.1038/s41598-019-47923-w.


Interferon-γ release assay as a sensitive diagnostic tool of latent tuberculosis infection in patients with HIV: a cross-sectional study.

Klautau G, da Mota N, Salles M, Burattini M, Rodrigues D BMC Infect Dis. 2018; 18(1):585.

PMID: 30453903 PMC: 6245697. DOI: 10.1186/s12879-018-3508-8.