Urinary Concentration and Dilution in the Aging Kidney

Overview

Journal Semin Nephrol

Specialty Nephrology

Date 2009 Dec 17

PMID 20006789

Citations 16

Authors

Jeff M Sands

Affiliations

Soon will be listed here.

Abstract

Aged people and rats have a reduced ability to maximally concentrate their urine. Many of the key transport proteins that contribute to urine concentrating ability are reduced in the medulla of aged rats. The reductions in the abundances of water, sodium, and urea transport proteins, and their reduced response to water restriction, contributes to the reduced ability of aged rats to concentrate their urine and conserve water. If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability.

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References

Tian Y, Riazi S, Khan O, Klein J, Sugimura Y, Verbalis J . Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats. Kidney Int. 2006; 69(2):304-12. DOI: 10.1038/sj.ki.5000076. View

Nielsen S, Terris J, Smith C, Hediger M, Ecelbarger C, Knepper M . Cellular and subcellular localization of the vasopressin- regulated urea transporter in rat kidney. Proc Natl Acad Sci U S A. 1996; 93(11):5495-500. PMC: 39274. DOI: 10.1073/pnas.93.11.5495. View

Klingler C, Preisser L, Barrault M, Lluel P, Horgen L, Teillet L . Vasopressin V2 receptor mRNA expression and cAMP accumulation in aging rat kidney. Am J Physiol. 1997; 272(6 Pt 2):R1775-82. DOI: 10.1152/ajpregu.1997.272.6.R1775. View

Fenton R, Moeller H, Hoffert J, Yu M, Nielsen S, Knepper M . Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc Natl Acad Sci U S A. 2008; 105(8):3134-9. PMC: 2268597. DOI: 10.1073/pnas.0712338105. View

Nielsen S, Frokiaer J, Marples D, Kwon T, Agre P, Knepper M . Aquaporins in the kidney: from molecules to medicine. Physiol Rev. 2002; 82(1):205-44. DOI: 10.1152/physrev.00024.2001. View

Edwards A, Pallone T . A multiunit model of solute and water removal by inner medullary vasa recta. Am J Physiol. 1998; 274(4):H1202-10. DOI: 10.1152/ajpheart.1998.274.4.H1202. View

Bagnasco S . Gene structure of urea transporters. Am J Physiol Renal Physiol. 2002; 284(1):F3-10. DOI: 10.1152/ajprenal.00260.2002. View

Bagnasco S, Peng T, Janech M, Karakashian A, Sands J . Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001; 281(3):F400-6. DOI: 10.1152/ajprenal.2001.281.3.F400. View

Sands J, Gargus J, Frohlich O, Gunn R, Kokko J . Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport. J Am Soc Nephrol. 1992; 2(12):1689-96. DOI: 10.1681/ASN.V2121689. View

10.

Blount M, Mistry A, Frohlich O, Price S, Chen G, Sands J . Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation. Am J Physiol Renal Physiol. 2008; 295(1):F295-9. PMC: 2494505. DOI: 10.1152/ajprenal.00102.2008. View

11.

Hoffert J, Nielsen J, Yu M, Pisitkun T, Schleicher S, Nielsen S . Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol. 2006; 292(2):F691-700. DOI: 10.1152/ajprenal.00284.2006. View

12.

LEVINSKY N, BERLINER R . The role of urea in the urine concentrating mechanism. J Clin Invest. 1959; 38(5):741-8. PMC: 293218. DOI: 10.1172/JCI103854. View

13.

Geelen G, Corman B . Relationship between vasopressin and renal concentrating ability in aging rats. Am J Physiol. 1992; 262(5 Pt 2):R826-33. DOI: 10.1152/ajpregu.1992.262.5.R826. View

14.

Brown D . The ins and outs of aquaporin-2 trafficking. Am J Physiol Renal Physiol. 2003; 284(5):F893-901. DOI: 10.1152/ajprenal.00387.2002. View

15.

Amlal H, Wilke C . Resistance of mTAL Na+-dependent transporters and collecting duct aquaporins to dehydration in 7-month-old rats. Kidney Int. 2003; 64(2):544-54. DOI: 10.1046/j.1523-1755.2003.00110.x. View

16.

Naruse M, Klein J, Ashkar Z, Jacobs J, Sands J . Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts. J Am Soc Nephrol. 1997; 8(4):517-23. DOI: 10.1681/ASN.V84517. View

17.

Combet S, Teillet L, Geelen G, Pitrat B, Gobin R, Nielsen S . Food restriction prevents age-related polyuria by vasopressin-dependent recruitment of aquaporin-2. Am J Physiol Renal Physiol. 2001; 281(6):F1123-31. DOI: 10.1152/ajprenal.0139.2001. View

18.

Preisser L, Teillet L, Aliotti S, Gobin R, Berthonaud V, Chevalier J . Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Am J Physiol Renal Physiol. 2000; 279(1):F144-52. DOI: 10.1152/ajprenal.2000.279.1.F144. View

19.

Sands J, Sidorowicz H, Klein J, Sladek C . Effect of age and testosterone on the vasopressin response to dehydration in F344BNF1 male rats. Adv Exp Med Biol. 1999; 449:183-5. DOI: 10.1007/978-1-4615-4871-3_22. View

20.

Yang B, Bankir L, Gillespie A, Epstein C, Verkman A . Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem. 2002; 277(12):10633-7. DOI: 10.1074/jbc.M200207200. View