Quantification of Renal Allograft Perfusion Using Arterial Spin Labeling MRI: Initial Results

Overview

Journal Eur Radiol

Specialty Radiology

Date 2009 Dec 2

PMID 19949799

Citations 42

Authors

Rotem S Lanzman

Hans-Jorg Wittsack

Petros Martirosian

Panagiota Zgoura

Philip Bilk

Patric Kropil

Fritz Schick

Adina Voiculescu

Dirk Blondin

Affiliations

Soon will be listed here.

Abstract

Objective: To quantify renal allograft perfusion in recipients with stable allograft function and acute decrease in allograft function using nonenhanced flow-sensitive alternating inversion recovery (FAIR)-TrueFISP arterial spin labeling (ASL) MR imaging.

Methods: Following approval of the local ethics committee, 20 renal allograft recipients were included in this study. ASL perfusion measurement and an anatomical T2-weighted single-shot fast spin-echo (HASTE) sequence were performed on a 1.5-T scanner (Magnetom Avanto, Siemens, Erlangen, Germany). T2-weighted MR urography was performed in patients with suspected ureteral obstruction. Patients were assigned to three groups: group a, 6 patients with stable allograft function over the previous 4 months; group b, 7 patients with good allograft function who underwent transplantation during the previous 3 weeks; group c, 7 allograft recipients with an acute deterioration of renal function.

Results: Mean cortical perfusion values were 304.8 +/- 34.4, 296.5 +/- 44.1, and 181.9 +/- 53.4 mg/100 ml/min for groups a, b and c, respectively. Reduction in cortical perfusion in group c was statistically significant.

Conclusion: Our results indicate that ASL is a promising technique for nonenhanced quantification of cortical perfusion of renal allografts. Further studies are required to determine the clinical value of ASL for monitoring renal allograft recipients.

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