Sialic Acids Acquired by Pseudomonas Aeruginosa Are Involved in Reduced Complement Deposition and Siglec Mediated Host-cell Recognition

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2009 Dec 1

PMID 19945458

Citations 47

Authors

Biswajit Khatua

Angana Ghoshal

Kaushik Bhattacharya

Chandan Mandal

Bibhuti Saha

Paul R Crocker

Chitra Mandal

Affiliations

Soon will be listed here.

Abstract

The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon. Culture of PA in the presence of exogenous Sia resulted in linkage-specific incorporation of Sia which was associated with decreased complement deposition on the bacteria. Sia acquired by PA mediated enhanced binding of bacteria to recombinant-CHO cells expressing human siglec-7 or siglec-9, as well as to human NK-cells and monocytes naturally expressing these siglecs. Therefore, Sia may be acquired by PA in the host and contribute to bacterial pathogenicity and host-cell interactions via reduction of complement deposition and siglec-dependent recognition.

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