The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2021 May 31

PMID 34055669

Citations 9

Authors

Taina Cavalcante

Mariana Medina Medeiros

Simon Ngao Mule

Giuseppe Palmisano

Beatriz Simonsen Stolf

Affiliations

Soon will be listed here.

Abstract

Carbohydrates or glycans are ubiquitous components of the cell surface which play crucial biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens. More than 20 pathogens can synthesize or capture Sias from their hosts and incorporate them into their own glycoconjugates and derivatives. Sialylation of pathogens' glycoconjugates may be crucial for survival inside the host for numerous reasons. The role of Sias in protozoa such as and was demonstrated in previous studies. This review highlights the importance of Sias in several pathogenic infections, focusing on . We describe in detail the contributions of Sias, Siglecs (sialic acid binding Ig-like lectins) and Neuraminidase 1 (NEU 1) in the course of infection. A detailed view on the structural and functional diversity of -related Sias and host-cell receptors will be provided, as well as the results of functional studies performed with different species.

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