Structure and Mechanism in Salivary Proteins from Blood-feeding Arthropods

Overview

Journal Toxicon

Specialty Toxicology

Date 2009 Nov 21

PMID 19925819

Citations 27

Authors

John F Andersen

Affiliations

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Abstract

The saliva of blood-feeding arthropods contains rich mixtures of ligand binding proteins targeted at inhibiting hemostasis and inflammation in the host. Since blood feeding has evolved many times, different taxonomic groups utilize completely different families of proteins to perform similar tasks. Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mechanistic studies are reviewed.

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