Fruits and Vegetables Consumption and the Risk of Histological Subtypes of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Overview

Journal Cancer Causes Control

Specialties Oncology
Public Health

Date 2009 Nov 20

PMID 19924549

Citations 32

Authors

F L Buchner

H B Bueno-de-Mesquita

J Linseisen

H C Boshuizen

L A L M Kiemeney

M M Ros

K Overvad

L Hansen

A Tjonneland

O Raaschou-Nielsen

F Clavel-Chapelon

M-C Boutron-Ruault

M Touillaud

R Kaaks

S Rohrmann

H Boeing

U Nothlings

A Trichopoulou

D Zylis

V Dilis

D Palli

S Sieri

P Vineis

R Tumino

S Panico

P H M Peeters

C H van Gils

E Lund

I T Gram

T Braaten

C Martinez

A Agudo

L Arriola

E Ardanaz

C Navarro

L Rodriguez

J Manjer

E Wirfalt

G Hallmans

T Rasmuson

T J Key

A W Roddam

S Bingham

K-T Khaw

N Slimani

P Bofetta

G Byrnes

T Norat

D Michaud

E Riboli

Affiliations

Soon will be listed here.

Abstract

Objective: To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study.

Methods: Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors.

Results: During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes.

Conclusion: We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.

Citing Articles

Effect of Fruit and Vegetable Consumption on Human Health: An Update of the Literature.

Devirgiliis C, Guberti E, Mistura L, Raffo A Foods. 2024; 13(19).

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Dietary factors and the risk of lung cancer by epidermal growth factor receptor mutation status and histological subtypes.

Yin X, Lai G, Seow A, Tan D, Lim D, Seow W Front Public Health. 2022; 10:1079543.

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Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study.

Yan F, Eshak E, Arafa A, Tamakoshi A, Iso H J Epidemiol. 2022; 33(10):536-542.

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Evidence Update on the Relationship between Diet and the Most Common Cancers from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: A Systematic Review.

Ubago-Guisado E, Rodriguez-Barranco M, Ching-Lopez A, Petrova D, Molina-Montes E, Amiano P Nutrients. 2021; 13(10).

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Dietary patterns with combined and site-specific cancer incidence in Alberta's Tomorrow Project cohort.

Willemsen R, McNeil J, Heer E, Johnson S, Friedenreich C, Brenner D Eur J Clin Nutr. 2021; 76(3):360-372.

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