D-aspartate Oxidase, a Peroxisomal Enzyme in Liver of Rat and Man

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1991 Jan 23

PMID 1991137

Citations 30

Authors

P P Van Veldhoven

C Brees

G P Mannaerts

Affiliations

Soon will be listed here.

Abstract

By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.

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