Inositol 1,3,4,6-tetrakisphosphate Mobilizes Calcium in Xenopus Oocytes with High Potency

Overview

Journal Biochem J

Specialty Biochemistry

Date 1991 Jan 15

PMID 1991032

Citations 6

Authors

I Ivorra

R GIGG

R F Irvine

I Parker

Affiliations

Soon will be listed here.

Abstract

Injection of Ins(1,3,4,6)P4 into Xenopus oocytes evoked Ca2(+)-dependent membrane currents with a potency 5-10 times less than Ins(1,4,5)P3, whereas Ins(1,3,4)P3 and Ins(1,3,4,5,6)P5 were almost ineffective. Responses to Ins(1,3,4,6)P4 arose through liberation of intracellular Ca2+ and through entry of extracellular Ca2+. These results, together with the observation that Ins(1,3,4,6)P4 facilitated responses to Ins(1,4,5)P3, suggests that both of these compounds may act on the same intracellular receptors.

Citing Articles

Intracellular Injection of Brain Extracts from Alzheimer's Disease Patients Triggers Unregulated Ca Release from Intracellular Stores That Hinders Cellular Bioenergetics.

Pensalfini A, Umar A, Glabe C, Parker I, Ullah G, Demuro A Cells. 2022; 11(22).

PMID: 36429057 PMC: 9688564. DOI: 10.3390/cells11223630.

Picomolar sensitivity to inositol trisphosphate in Xenopus oocytes.

Demuro A, Parker I Cell Calcium. 2015; 58(5):511-7.

PMID: 26344104 PMC: 4708890. DOI: 10.1016/j.ceca.2015.08.003.

Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents.

Machaca K, HC Hartzell J Gen Physiol. 1999; 113(2):249-66.

PMID: 9925823 PMC: 2223373. DOI: 10.1085/jgp.113.2.249.

Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.

Hirata M, Takeuchi H, Riley A, Mills S, Watanabe Y, Potter B Biochem J. 1998; 328 ( Pt 1):93-8.

PMID: 9359838 PMC: 1218891. DOI: 10.1042/bj3280093.

D-myo-inositol 1,3,4,5-tetrakisphosphate releases Ca2+ from crude microsomes and enriched vesicular plasma membranes, but not from intracellular stores of permeabilized T-lymphocytes and monocytes.

Guse A, Roth E, Emmrich F Biochem J. 1992; 288 ( Pt 2):489-95.

PMID: 1463453 PMC: 1132037. DOI: 10.1042/bj2880489.

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