Caspase 2 in Apoptosis, the DNA Damage Response and Tumour Suppression: Enigma No More?

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2009 Nov 6

PMID 19890334

Citations 81

Authors

Sharad Kumar

Affiliations

Soon will be listed here.

Abstract

Aberrations in proteins that control apoptosis and cell survival are common in cancer. These aberrations often reside in signalling proteins that control the activation of the apoptotic machinery or in the Bcl-2 family of proteins that control caspase activation. Recent evidence suggests that caspase 2, one of the most evolutionarily conserved caspases, may have multiple roles in the DNA damage response, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis and the treatment of cancer.

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