Synthesis of Fluorescent C24-ceramide: Evidence for Acyl Chain Length Dependent Differences in Penetration of Exogenous NBD-ceramides into Human Skin

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2009 Nov 3

PMID 19879139

Citations 7

Authors

Jakub Novotny

Katerina Pospechova

Alexandr Hrabalek

Robert cap

Katerina Vavrova

Affiliations

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Abstract

Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools.

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