THE MULTIPLICATION OF BACTERIOPHAGE IN VIVO AND ITS PROTECTIVE EFFECT AGAINST AN EXPERIMENTAL INFECTION WITH SHIGELLA DYSENTERIAE

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2009 Oct 30

PMID 19871319

Citations 39

Authors

R J DUBOS

J H Straus

C Pierce

Affiliations

Soon will be listed here.

Abstract

1. Anti-Shiga bacteriophage injected into the general circulation can multiply in the brain of mice infected intracerebrally with Shigella dysenteriae. 2. Under proper conditions, the injection of active bacteriophage into the general circulation can protect mice against an otherwise fatal intracerebral infection with Shigella dysenteriae. 3. The protection so induced appears to depend upon the early establishment of a high bacteriophage level in the infected animal.

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References

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