NEUTRALIZATION OF INFLUENZA A VIRUS BY HUMAN SERUM

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2009 Oct 30

PMID 19871081

Citations 5

Authors

F L Horsfall

E H LENNETTE

Affiliations

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Abstract

A linear relationship exists between the quantity of human serum used and the quantity of influenza A virus neutralized. By means of this relationship it is possible to determine the maximum quantity of virus which a given human serum can neutralize. This quantity, the neutralizing capacity, is a fixed value and, unlike the serum dilution end point, is independent of the amount of virus used in the neutralization test.

Citing Articles

STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : I. THE PRECISION OF MEASUREMENTS IN VIVO OF THE VIRUS AND ANTIBODIES AGAINST IT.

Horsfall F, CURNEN E J Exp Med. 2009; 83(1):25-42.

PMID: 19871514 PMC: 2135573.

NEUTRALIZING ANTIBODIES IN HUMAN SERUM AFTER INFLUENZA A : THE LACK OF STRAIN SPECIFICITY IN THE IMMUNOLOGICAL RESPONSE.

Horsfall F, Rickard E J Exp Med. 2009; 74(5):433-9.

PMID: 19871146 PMC: 2135195. DOI: 10.1084/jem.74.5.433.

STUDIES ON INFLUENZA VIRUS : THE COMPLEMENT-FIXING ANTIGEN OF INFLUENZA A AND SWINE INFLUENZA VIRUSES.

LENNETTE E, Horsfall F J Exp Med. 2009; 73(5):581-99.

PMID: 19871098 PMC: 2135149. DOI: 10.1084/jem.73.5.581.

A COMPLEX VACCINE AGAINST INFLUENZA A VIRUS : QUANTITATIVE ANALYSIS OF THE ANTIBODY RESPONSE PRODUCED IN MAN.

Horsfall F, LENNETTE E, Rickard E J Exp Med. 2009; 73(3):335-55.

PMID: 19871082 PMC: 2135134. DOI: 10.1084/jem.73.3.335.

Neutralization of viruses by homologous immune serum. I. Quantitative studies on factors which affect the neutralization reaction with Newcastle disease, influenza A, and bacterial virus T3.

Tyrrell D, HORSFALL Jr F J Exp Med. 1953; 97(6):845-61.

PMID: 13069640 PMC: 2136315. DOI: 10.1084/jem.97.6.845.

References

Horsfall F, Hahn R, Rickard E . FOUR RECENT INFLUENZA EPIDEMICS: AN EXPERIMENTAL STUDY. J Clin Invest. 1940; 19(2):379-92. PMC: 434972. DOI: 10.1172/JCI101140. View

Horsfall F . NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED. J Exp Med. 2009; 70(2):209-22. PMC: 2133786. DOI: 10.1084/jem.70.2.209. View