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THE EFFECT OF EXPERIMENTAL REDUCTION OF KIDNEY SUBSTANCE UPON THE PARATHYROID GLANDS AND SKELETAL TISSUE

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Journal J Exp Med
Date 2009 Oct 30
PMID 19870581
Citations 4
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Abstract

Reduction of renal tissue in young rats regularly leads to a marked increase in the volume of the parathyroid glands. If partially nephrectomized rats are maintained on a low calcium diet, growth is stunted, and skeletal lesions are produced, of far greater severity than can be ascribed to the dietary calcium deficiency alone. The picture closely resembles that found in cases of renal rickets in children.

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The experimental induction of parathyroid hyperplasia in rats, and the use of toluidine blue O for in vivo identification of parathyroid tissue.

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