SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2009 Oct 30

PMID 19867290

Citations 4

Authors

A S WEISBERGER

T M Daniel

A Hoffman

Affiliations

Soon will be listed here.

Abstract

Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol administered. The mechanism of action of chloramphenicol in suppressing immune responses is correlated with its ability to inhibit protein synthesis in proliferating mammalian cells. These observations suggest that the inhibitory effect of chloramphenicol on protein synthesis may be applicable to mammalian cells in vivo as well as to cell-free systems and to intact mammalian cells in vivo.

Citing Articles

Effect of x- radiation and 6-MP on the secondary antibody response.

Jilek M, STERZL J Folia Microbiol (Praha). 1967; 12(1):21-30.

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[Mechanism of action of chloramphenical in the inhibition of antibody production induced by different types of antigens].

MICHELAZZI L, Marinari U, BALDINI I Experientia. 1968; 24(12):1268-70.

PMID: 4883336 DOI: 10.1007/BF02146666.

[The amyloidoses].

Bruns G Klin Wochenschr. 1967; 45(17):868-74.

PMID: 4875335 DOI: 10.1007/BF01745683.

The effect of common antibiotics on lymphocyte transformation.

Dam W, MALKINSON F, Gewurz H Experientia. 1975; 31(3):375-6.

PMID: 1116556 DOI: 10.1007/BF01922595.

References

Bauer D, Stavitsky A . ON THE DIFFERENT MOLECULAR FORMS OF ANTIBODY SYNTHESIZED BY RABBITS DURING THE EARLY RESPONSE TO A SINGLE INJECTION OF PROTEIN AND CELLULAR ANTIGENS. Proc Natl Acad Sci U S A. 1961; 47(10):1667-80. PMC: 223190. DOI: 10.1073/pnas.47.10.1667. View

Daniel T, WEYAND Jr J, Stavitsky A . MICROMETHODS FOR THE STUDY OF PROTEINS AND ANTIBODIES. IV. FACTORS INVOLVED IN THE PREPARATION AND USE OF A STABLE PREPARATION OF FORMALINIZED, TANNIC ACID-TREATED, PROTEIN-SENSITIZED ERYTHROCYTES FOR DETECTION OF ANTIGEN AND ANTIBODY. J Immunol. 1963; 90:741-50. View

MEEKER Jr W, Condie R, GOOD R, VARCO R . Alteration of the homograft response by antimetabolites. Ann N Y Acad Sci. 1960; 87:203-13. DOI: 10.1111/j.1749-6632.1960.tb23193.x. View

SUHRLAND L, WEISBERGER A . CHLORAMPHENICOL TOXICITY IN LIVER AND RENAL DISEASE. Arch Intern Med. 1963; 112:747-54. DOI: 10.1001/archinte.1963.03860050134016. View

Schwartz R, Stack J, DAMESHEK W . Effect of 6-mercaptopurine on antibody production. Proc Soc Exp Biol Med. 1958; 99(1):164-7. DOI: 10.3181/00379727-99-24281. View

WEISBERGER A, Wolfe S, ARMENTROUT S . INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELL-FREE SYSTEMS BY CHLORAMPHENICOL. J Exp Med. 1964; 120:161-81. PMC: 2137725. DOI: 10.1084/jem.120.2.161. View

Ambrose C, Coons A . Studies on antibody production. VIII. The inhibitory effect of chloramphenicol on the synthesis of antibody in tissue culture. J Exp Med. 1963; 117:1075-88. PMC: 2137591. DOI: 10.1084/jem.117.6.1075. View

GLAZKO A, Wolf L, DILL W . Biochemical studies on chloramphenicol; colorimetric methods for the determination of chloramphenicol and related nitro compounds. Arch Biochem. 1949; 23(3):411-8. View

Edelman G, KUNKEL H, FRANKLIN E . Interaction of the rheumatoid factor with antigen-antibody complexes and aggregated gamma globulin. J Exp Med. 1958; 108(1):105-20. PMC: 2136886. DOI: 10.1084/jem.108.1.105. View

10.

LAPLANTE E, Condie R, GOOD R . Prevention of secondary immune response with 6-mercaptopurine. J Lab Clin Med. 1962; 59:542-9. View

11.

Schwartz R, DAMESHEK W . Drug-induced immunological tolerance. Nature. 1959; 183(4676):1682-3. DOI: 10.1038/1831682a0. View

12.

McGregor D, Gowans J . THE ANTIBODY RESPONSE OF RATS DEPLETED OF LYMPHOCYTES BY CHRONIC DRAINAGE FROM THE THORACIC DUCT. J Exp Med. 2009; 117(2):303-20. PMC: 2137611. DOI: 10.1084/jem.117.2.303. View

13.

WEISBERGER A, ARMENTROUT S, Wolfe S . Protein synthesis by reticulocyte ribosomes. I. Inhibition of polyuridylic acid-induced ribosomal protein synthesis by chloramphenical. Proc Natl Acad Sci U S A. 1963; 50:86-93. PMC: 300658. DOI: 10.1073/pnas.50.1.86. View

14.

Schwartz R, DAMESHEK W . The effects of 6-mercaptopurine on homograft reactions. J Clin Invest. 1960; 39:952-8. PMC: 441842. DOI: 10.1172/JCI104116. View

15.

Schwartz R, Eisner A, DAMESHEK W . The effect of 6-mercaptopurine on primary and secondary immune responses. J Clin Invest. 1959; 38(8):1394-403. PMC: 442094. DOI: 10.1172/JCI103915. View

16.

Farhi A, LAMENSANS A . [Effect of antibiotics on immunity. I. Effect of chloramphenicol on antibody production in the presence of a soluble antigen]. C R Hebd Seances Acad Sci. 1955; 241(24):1894-6. View