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CORRELATION OF PRODUCTION OF INFECTIOUS VIRUS WITH SEQUENTIAL STAGES OF CYTOLOGIC ALTERATION IN HELA CELLS INFECTED WITH ADENOVIRUSES TYPES 5 AND 7

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 2009 Oct 30
PMID 19867181
Citations 1
Authors
G S Boyer
F W Denny
I Miller
H S Ginsberg
Affiliations
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Abstract

Studies correlating the production of infectious adenovirus (types 5 and 7) and the progression of the stages of virus-induced cytologic change in HeLa cells are presented. The results reveal a close relationship between the development of the characteristic nuclear changes and adenovirus synthesis. They suggest that cells manifesting the first stages of nuclear change, characterized by the appearance of eosinophilic, Feulgen-negative inclusions, contain little or no mature infectious virus, whereas cells in the later stages, with Feulgen-positive and basophilic inclusions, contain relatively large amounts.

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