HIV and the Kidney

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2009 Oct 28

PMID 19857388

Citations 9

Authors

Leslie A Bruggeman

Charles Bark

Robert C Kalayjian

Affiliations

Soon will be listed here.

Abstract

Direct effects of HIV-1 infection on the kidney combine with immune and genetic factors, comorbidities, coinfections, and medication toxicities to induce a spectrum of kidney disorders in HIV disease. The most dramatic of these, HIV-associated nephropathy (HIVAN), emerges almost exclusively in persons of African descent and is associated with rapid progression to end-stage renal disease in the absence of antiretroviral therapy (ART). ART modifies the natural history of HIVAN, but the renal benefits of ART may not be limited to HIVAN. ART is often under prescribed or incorrectly dosed in persons with kidney disease. Vigilant attention to renal function and an understanding of the complex associations involving the kidneys are necessary for optimal care of these patients.

Citing Articles

Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria.

Wudil U, Aliyu M, Prigmore H, Ingles D, Ahonkhai A, Musa B Kidney Int. 2021; 100(1):146-154.

PMID: 33901548 PMC: 8487768. DOI: 10.1016/j.kint.2021.03.038.

Prevalence of chronic kidney disease among HIV-1-infected patients receiving a combination antiretroviral therapy.

Calza L, Sachs M, Colangeli V, Borderi M, Granozzi B, Malosso P Clin Exp Nephrol. 2019; 23(11):1272-1279.

PMID: 31327092 DOI: 10.1007/s10157-019-01768-9.

Renal Function in Chinese HIV-Positive Individuals following Initiation of Antiretroviral Therapy.

Zhao Y, Zhang M, Shi C, Zhang Y, Cai W, Zhao Q PLoS One. 2015; 10(8):e0135462.

PMID: 26317657 PMC: 4552675. DOI: 10.1371/journal.pone.0135462.

Prevalence of persistent microalbuminuria and associated factors among HIV infected children attending a Tertiary Hospital in Northern Tanzania: a cross sectional, analytical study.

Mosten I, Hamel B, Kinabo G Pan Afr Med J. 2015; 20:251.

PMID: 26161174 PMC: 4483356. DOI: 10.11604/pamj.2015.20.251.5429.

Kidney Dysfunction and Markers of Inflammation in the Multicenter AIDS Cohort Study.

Abraham A, Darilay A, McKay H, Margolick J, Estrella M, Palella Jr F J Infect Dis. 2015; 212(7):1100-10.

PMID: 25762788 PMC: 4559190. DOI: 10.1093/infdis/jiv159.

References

Lucas G, Eustace J, Sozio S, Mentari E, Appiah K, Moore R . Highly active antiretroviral therapy and the incidence of HIV-1-associated nephropathy: a 12-year cohort study. AIDS. 2004; 18(3):541-6. DOI: 10.1097/00002030-200402200-00022. View

ODonnell M, Chao C, Gekker G, Modi K, Kasiske B, Keane W . Renal cell cytokine production stimulates HIV-1 expression in chronically HIV-1-infected monocytes. Kidney Int. 1998; 53(3):593-7. DOI: 10.1046/j.1523-1755.1998.00789.x. View

Kiryluk K, Martino J, Gharavi A . Genetic susceptibility, HIV infection, and the kidney. Clin J Am Soc Nephrol. 2007; 2 Suppl 1:S25-35. DOI: 10.2215/CJN.00320107. View

Zhong J, Zuo Y, Ma J, Fogo A, Jolicoeur P, Ichikawa I . Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int. 2005; 68(3):1048-60. DOI: 10.1111/j.1523-1755.2005.00497.x. View

Cohen A, Sun N, Shapshak P, IMAGAWA D . Demonstration of human immunodeficiency virus in renal epithelium in HIV-associated nephropathy. Mod Pathol. 1989; 2(2):125-8. View

Tourret J, Tostivint I, Tezenas du Montcel S, Karie S, Launay-Vacher V, Vigneau C . Antiretroviral drug dosing errors in HIV-infected patients undergoing hemodialysis. Clin Infect Dis. 2007; 45(6):779-84. DOI: 10.1086/521168. View

Winston J, Deray G, Hawkins T, Szczech L, Wyatt C, Young B . Kidney disease in patients with HIV infection and AIDS. Clin Infect Dis. 2008; 47(11):1449-57. DOI: 10.1086/593099. View

Cohen S, Kimmel P . Immune complex renal disease and human immunodeficiency virus infection. Semin Nephrol. 2008; 28(6):535-44. DOI: 10.1016/j.semnephrol.2008.08.006. View

I de Silva T, Post F, Griffin M, Dockrell D . HIV-1 infection and the kidney: an evolving challenge in HIV medicine. Mayo Clin Proc. 2007; 82(9):1103-16. DOI: 10.4065/82.9.1103. View

10.

Sunamoto M, Husain M, He J, Schwartz E, Klotman P . Critical role for Nef in HIV-1-induced podocyte dedifferentiation. Kidney Int. 2003; 64(5):1695-701. DOI: 10.1046/j.1523-1755.2003.00283.x. View

11.

Brenchley J, Price D, Schacker T, Asher T, Silvestri G, Rao S . Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006; 12(12):1365-71. DOI: 10.1038/nm1511. View

12.

Fine D, Fogo A, Alpers C . Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patient. Semin Nephrol. 2008; 28(6):545-55. DOI: 10.1016/j.semnephrol.2008.08.007. View

13.

Baenziger S, Heikenwalder M, Johansen P, Schlaepfer E, Hofer U, Miller R . Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood. 2008; 113(2):377-88. DOI: 10.1182/blood-2008-04-151712. View

14.

Gupta S, Eustace J, Winston J, Boydstun I, Ahuja T, Rodriguez R . Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2005; 40(11):1559-85. DOI: 10.1086/430257. View

15.

Gallant J, Winston J, DeJesus E, Pozniak A, Chen S, Cheng A . The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients. AIDS. 2008; 22(16):2155-63. DOI: 10.1097/QAD.0b013e3283112b8e. View

16.

Bruggeman L, Dikman S, Meng C, Quaggin S, Coffman T, Klotman P . Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Invest. 1997; 100(1):84-92. PMC: 508168. DOI: 10.1172/JCI119525. View

17.

Peters P, Moore D, Mermin J, Brooks J, Downing R, Were W . Antiretroviral therapy improves renal function among HIV-infected Ugandans. Kidney Int. 2008; 74(7):925-9. DOI: 10.1038/ki.2008.305. View

18.

Marras D, Bruggeman L, Gao F, Tanji N, Mansukhani M, Cara A . Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med. 2002; 8(5):522-6. DOI: 10.1038/nm0502-522. View

19.

Kuller L, Tracy R, Belloso W, De Wit S, Drummond F, Lane H . Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 2008; 5(10):e203. PMC: 2570418. DOI: 10.1371/journal.pmed.0050203. View

20.

Szczech L, Gupta S, Habash R, Guasch A, Kalayjian R, Appel R . The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection. Kidney Int. 2004; 66(3):1145-52. DOI: 10.1111/j.1523-1755.2004.00865.x. View