Accelerated Aging in HIV Patients

Overview

Journal Rambam Maimonides Med J

Specialty General Medicine

Date 2013 Aug 3

PMID 23908849

Citations 21

Authors

Keren Meir-Shafrir

Shimon Pollack

Affiliations

Soon will be listed here.

Abstract

Life expectancy has been increasing in the last few decades in the Western world and is accompanied by higher occurrence of age-related diseases like metabolic, cardiovascular, and renal diseases and also with a decline in immune functions. In HIV-infected people, due to the use of combination antiretroviral therapy (cART), life expectancy has increased. As a result, non-AIDS conditions which are age-associated have become more prevalent and appear earlier, resulting in accelerated aging in HIV patients. These non-AIDS conditions in HIV patients are associated with CD4+ T cell counts: lower counts are associated with higher rates of liver, cardiovascular, renal, and neurocognitive disorders. The effect of viral load and cART on the earlier occurrence of age-associated diseases is less significant than the CD4 count effect. Thus, the loss of immune functions in HIV-infected patients may enhance aging.

Citing Articles

A Comprehensive Review of the Manifestation of Cardiovascular Diseases in HIV Patients.

Abarca Y, Chadalavada B, Ceron J, Sai B, Bhatia A, Espinoza I Cureus. 2025; 17(1):e77509.

PMID: 39958097 PMC: 11828753. DOI: 10.7759/cureus.77509.

Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling.

Ham L, Roesch S, Franklin D, Ellis R, Grant I, Moore D AIDS Behav. 2025; .

PMID: 39928071 DOI: 10.1007/s10461-025-04623-z.

Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging.

Dye C, Wu H, Jackson G, Kidane A, Nkambule R, Lukhele N Clin Epigenetics. 2024; 16(1):32.

PMID: 38403593 PMC: 10895753. DOI: 10.1186/s13148-024-01629-7.

Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice.

Zhang C, Su H, Waight E, Poluektova L, Gorantla S, Gendelman H Pharmaceuticals (Basel). 2024; 17(2).

PMID: 38399364 PMC: 10892358. DOI: 10.3390/ph17020149.

Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging.

Dye C, Wu H, Jackson G, Kidane A, Nkambule R, Lukhele N Res Sq. 2023; .

PMID: 37886587 PMC: 10602087. DOI: 10.21203/rs.3.rs-3389208/v1.

References

Bestilny L, Gill M, Mody C, Riabowol K . Accelerated replicative senescence of the peripheral immune system induced by HIV infection. AIDS. 2000; 14(7):771-80. DOI: 10.1097/00002030-200005050-00002. View

Friis-Moller N, Reiss P, Sabin C, Weber R, Monforte A, El-Sadr W . Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007; 356(17):1723-35. DOI: 10.1056/NEJMoa062744. View

Bhatia R, Ryscavage P, Taiwo B . Accelerated aging and human immunodeficiency virus infection: emerging challenges of growing older in the era of successful antiretroviral therapy. J Neurovirol. 2011; 18(4):247-55. DOI: 10.1007/s13365-011-0073-y. View

Simioni S, Cavassini M, Annoni J, Rimbault Abraham A, Bourquin I, Schiffer V . Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS. 2009; 24(9):1243-50. DOI: 10.1097/QAD.0b013e3283354a7b. View

Kalayjian R, Landay A, Pollard R, Taub D, Gross B, Francis I . Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis. 2003; 187(12):1924-33. DOI: 10.1086/375372. View

Lohse N, Hansen A, Pedersen G, Kronborg G, Gerstoft J, Sorensen H . Survival of persons with and without HIV infection in Denmark, 1995-2005. Ann Intern Med. 2007; 146(2):87-95. DOI: 10.7326/0003-4819-146-2-200701160-00003. View

Bruggeman L, Bark C, Kalayjian R . HIV and the Kidney. Curr Infect Dis Rep. 2009; 11(6):479-85. PMC: 2789290. DOI: 10.1007/s11908-009-0069-4. View

Hearps A, Maisa A, Cheng W, Angelovich T, Lichtfuss G, Palmer C . HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy. AIDS. 2012; 26(7):843-53. DOI: 10.1097/QAD.0b013e328351f756. View

Bolland M, Grey A, Horne A, Briggs S, Thomas M, Ellis-Pegler R . Bone mineral density remains stable in HAART-treated HIV-infected men over 2 years. Clin Endocrinol (Oxf). 2007; 67(2):270-5. DOI: 10.1111/j.1365-2265.2007.02875.x. View

10.

Desquilbet L, Jacobson L, Fried L, Phair J, Jamieson B, Holloway M . HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007; 62(11):1279-86. DOI: 10.1093/gerona/62.11.1279. View

11.

Hsue P, Hunt P, Schnell A, Kalapus S, Hoh R, Ganz P . Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis. AIDS. 2009; 23(9):1059-67. PMC: 2691772. DOI: 10.1097/QAD.0b013e32832b514b. View

12.

Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm D . A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS. 1998; 12(7):F51-8. DOI: 10.1097/00002030-199807000-00003. View

13.

Heaton R, Franklin D, Ellis R, McCutchan J, Letendre S, LeBlanc S . HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2010; 17(1):3-16. PMC: 3032197. DOI: 10.1007/s13365-010-0006-1. View

14.

Choi A, Scherzer R, Bacchetti P, Tien P, Saag M, Gibert C . Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected persons. Am J Kidney Dis. 2010; 56(5):872-82. PMC: 3164880. DOI: 10.1053/j.ajkd.2010.05.019. View

15.

Hunt P, Brenchley J, Sinclair E, McCune J, Roland M, Page-Shafer K . Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis. 2008; 197(1):126-33. PMC: 3466592. DOI: 10.1086/524143. View

16.

Kogut I, Scholz J, Cancro M, Cambier J . B cell maintenance and function in aging. Semin Immunol. 2012; 24(5):342-9. DOI: 10.1016/j.smim.2012.04.004. View

17.

Shah K, Hilton T, Myers L, Pinto J, Luque A, Hall W . A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus. J Am Geriatr Soc. 2012; 60(3):545-9. PMC: 3302930. DOI: 10.1111/j.1532-5415.2011.03819.x. View

18.

Shlay J, Sharma S, Peng G, Gibert C, Grunfeld C . The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009; 51(3):298-304. PMC: 2745266. DOI: 10.1097/QAI.0b013e3181aa1308. View

19.

Lo J, Abbara S, Shturman L, Soni A, Wei J, Rocha-Filho J . Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men. AIDS. 2009; 24(2):243-53. PMC: 3154841. DOI: 10.1097/QAD.0b013e328333ea9e. View

20.

Dolan S, Kanter J, Grinspoon S . Longitudinal analysis of bone density in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 2006; 91(8):2938-45. PMC: 3207203. DOI: 10.1210/jc.2006-0127. View