Caries is Associated with Asthma and Epilepsy

Overview

Journal Eur J Dent

Publisher Thieme

Specialty Dentistry

Date 2009 Oct 15

PMID 19826602

Citations 19

Authors

Ida Anjomshoaa

Margaret E Cooper

Alexandre R Vieira

Affiliations

Soon will be listed here.

Abstract

Objectives: There is evidence of association between systemic diseases and oral conditions, although it is not clear if these are direct or mediated by underlying factors such as health behaviors. The aim of this work was to evaluate whether self-reported systemic diseases were associated with caries experience.

Methods: Medical history data and caries experience (DMFT and DMFS; Decayed, Missing due to caries, Filled Teeth/Surface) were obtained from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository. Information on 318 subjects (175 females and 143 males) was evaluated. Regression analysis was used to test for association between caries experience and disease status.

Results: The stronger associations were found between caries experience and asthma and epilepsy. With respect to asthma, DMFT above 15 (R(2) = 0.04) and DMFS above 50 (R(2) = 0.02) were associated. After controlling for gender differences in asthma, the associations remained strong (R(2) = 0.05 for both DMFT and DMFS). For epilepsy, DMFT above 15 (R(2) = 0.18) and DMFS above 50 (R(2) = 0.14) were associated.

Conclusions: Asthma and epilepsy are associated with higher caries experience.

Citing Articles

An overlooked connection: oral health status in patients with chronic diseases.

Ocbe M, Celebi E, Ocbe C BMC Oral Health. 2025; 25(1):314.

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The relationship between dental caries with asthma, disease duration, and type of medications in the Azar cohort population.

Katebi K, Ashkannejhad S, Mahboobi Z, Faramarzi E, Sharififard N BMC Oral Health. 2024; 24(1):1511.

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A comparative evaluation of the effects of respiratory diseases on dental caries.

Ucuncu M, Topcuoglu N, Kulekci G, Ucuncu M, Erelel M, Gokce Y BMC Oral Health. 2024; 24(1):13.

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Comparison of dental caries (DMFT and DMFS indices) between asthmatic patients and control group in Iran: a meta-analysis.

Gorji N, Nasiri P, Malekzadeh Shafaroudi A, Moosazadeh M Asthma Res Pract. 2021; 7(1):2.

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Aquaporin locus (12q13.12) might contribute to susceptibility of temporomandibular joint disorder associated with periodontitis.

Bezamat M, Cunha E, Modesto A, Vieira A, Taboas J PLoS One. 2020; 15(3):e0229245.

PMID: 32130259 PMC: 7055872. DOI: 10.1371/journal.pone.0229245.

References

Steinbacher D, Glick M . The dental patient with asthma. An update and oral health considerations. J Am Dent Assoc. 2001; 132(9):1229-39. DOI: 10.14219/jada.archive.2001.0365. View

Shulman J, Taylor S, Nunn M . The association between asthma and dental caries in children and adolescents: A population-based case-control study. Caries Res. 2001; 35(4):240-6. DOI: 10.1159/000047464. View

Riley 3rd J, Gilbert G, Heft M . Socioeconomic and demographic disparities in symptoms of orofacial pain. J Public Health Dent. 2003; 63(3):166-73. DOI: 10.1111/j.1752-7325.2003.tb03495.x. View

Arnrup K, Lundin S, Dahllof G . Analysis of paediatric dental services provided at a regional hospital in Sweden. Dental treatment need in medically compromised children referred for dental consultation. Swed Dent J. 1993; 17(6):255-9. View

Lukacs J, Largaespada L . Explaining sex differences in dental caries prevalence: saliva, hormones, and "life-history" etiologies. Am J Hum Biol. 2006; 18(4):540-55. DOI: 10.1002/ajhb.20530. View

Deshpande A, Harris-Hayes M, Schootman M . Epidemiology of diabetes and diabetes-related complications. Phys Ther. 2008; 88(11):1254-64. PMC: 3870323. DOI: 10.2522/ptj.20080020. View

Lutfiyya M, Nika B, Ng L, Tragos C, Won R, Lipsky M . Primary prevention of overweight and obesity: an analysis of national survey data. J Gen Intern Med. 2008; 23(6):821-3. PMC: 2517882. DOI: 10.1007/s11606-008-0581-5. View

Ersin N, Gulen F, Eronat N, Cogulu D, Demir E, Tanac R . Oral and dental manifestations of young asthmatics related to medication, severity and duration of condition. Pediatr Int. 2006; 48(6):549-54. DOI: 10.1111/j.1442-200X.2006.02281.x. View

Deeley K, Letra A, ROSE E, Brandon C, Resick J, Marazita M . Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population. Caries Res. 2007; 42(1):8-13. PMC: 2814012. DOI: 10.1159/000111744. View

10.

Reddy D, M Hegde A, Munshi A . Dental caries status of children with bronchial asthma. J Clin Pediatr Dent. 2003; 27(3):293-5. View

11.

Kay E . How often should we go to the dentist?. BMJ. 1999; 319(7204):204-5. PMC: 1116309. DOI: 10.1136/bmj.319.7204.204. View

12.

Eloot A, Vanobbergen J, De Baets F, Martens L . Oral health and habits in children with asthma related to severity and duration of condition. Eur J Paediatr Dent. 2004; 5(4):210-5. View

13.

Rajavaara P, Vainionpaa L, Rattya J, Knip M, Pakarinen A, Isojarvi J . Tooth by tooth survival analysis of dental health in girls with epilepsy. Eur J Paediatr Dent. 2003; 4(2):72-7. View

14.

Green B, Person S, Crowther M, Frison S, Shipp M, Lee P . Demographic and geographic variations of oral health among African Americans based on NHANES III. Community Dent Health. 2003; 20(2):117-22. View

15.

Ryberg M, Moller C, Ericson T . Effect of beta 2-adrenoceptor agonists on saliva proteins and dental caries in asthmatic children. J Dent Res. 1987; 66(8):1404-6. DOI: 10.1177/00220345870660082401. View

16.

Patir A, Seymen F, Yildirim M, Deeley K, Cooper M, Marazita M . Enamel formation genes are associated with high caries experience in Turkish children. Caries Res. 2008; 42(5):394-400. PMC: 2820320. DOI: 10.1159/000154785. View

17.

. Medical evaluations of healthy persons. Council on Scientific Affairs. JAMA. 1983; 249(12):1626-33. View

18.

. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007; 120(5 Suppl):S94-138. DOI: 10.1016/j.jaci.2007.09.043. View

19.

Ryberg M, Moller C, Ericson T . Saliva composition and caries development in asthmatic patients treated with beta 2-adrenoceptor agonists: a 4-year follow-up study. Scand J Dent Res. 1991; 99(3):212-8. DOI: 10.1111/j.1600-0722.1991.tb01887.x. View

20.

Vieira A, Marazita M, Goldstein-McHenry T . Genome-wide scan finds suggestive caries loci. J Dent Res. 2008; 87(5):435-9. DOI: 10.1177/154405910808700506. View