Autophagy, Immunity and Human Disease

Overview

Journal Curr Opin Gastroenterol

Specialty Gastroenterology

Date 2009 Oct 15

PMID 19826372

Citations 20

Authors

Robert J Heath

Ramnik J Xavier

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: To give an overview of autophagy and its effects on innate and adaptive immunity and touch on some of the roles of autophagy in disease.

Recent Findings: Precise regulation of autophagy is necessary to maintain metabolic equilibrium, immune homeostasis, delineate cell fate and influence host cell responses to cytosolic pathogens. A growing number of studies have implicated that inactivation of autophagy-selective responses contributes to inflammatory disorders, neurodegeneration and cancer, but the precise steps at which disease-associated autophagy-related (ATG) genes affect autophagy pathways is unknown at present.

Summary: In eukaryotic cells autophagy is constitutively active at low levels, whereas significant up-regulation occurs in response to a multitude of stresses. Autophagy has achieved notoriety as a perturbed biological process in many disease states and an exponential increase of studies attribute roles for autophagy in innate and adaptive immunity. Understanding how individual disease-associated ATG genes function will lead to a better understanding of and potentially novel therapies for treating the diseases in which they are involved.

Citing Articles

Changes in inflammatory responses and autophagy during apheresis platelet preservation and their correlation with platelet transfusion refractoriness in patients with acute lymphoblastic leukemia.

Li Y, Song Z, Sun X, Tang J, Zhou X Biomol Biomed. 2023; 23(6):956-967.

PMID: 37401750 PMC: 10655888. DOI: 10.17305/bb.2023.9216.

Pouchitis: insight into the pathogenesis and clinical aspects.

de Negreiros L, Pascoal L, Genaro L, Silva J, Rodrigues B, Camargo M Am J Transl Res. 2022; 14(7):4406-4425.

PMID: 35958439 PMC: 9360866.

Taming the Autophagy as a Strategy for Treating COVID-19.

Garcia-Perez B, Gonzalez-Rojas J, Salazar M, Torres-Torres C, Castrejon-Jimenez N Cells. 2020; 9(12).

PMID: 33322168 PMC: 7764362. DOI: 10.3390/cells9122679.

The Effect of Autophagic Activity on the Function of Apheresis Platelets and on the Efficacy of Clinical Platelet Transfusion.

Tang H, Gao M, Fu Y, Gui R, Ma X Transfus Med Hemother. 2020; 47(4):302-313.

PMID: 32884503 PMC: 7443674. DOI: 10.1159/000504764.

Typically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis.

Xu F, Ma Y, Huang W, Gao J, Guo M, Li J Cell Death Dis. 2020; 11(8):666.

PMID: 32820146 PMC: 7441392. DOI: 10.1038/s41419-020-02898-9.

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