VEGF -460C>T Polymorphism and Cancer Risk: a Meta-analysis

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2009 Oct 10

PMID 19816815

Citations 11

Authors

Bin Xu

Ning-Han Feng

Na Tong

Zi-Dun Wang

Wei Zhang

Hong-Fei Wu

Lin-Xin Hua

Affiliations

Soon will be listed here.

Abstract

Vascular endothelial growth factor (VEGF) is a major driver of physiological and pathological angiogenesis and plays important roles in the etiology and metastasis of cancers. The -460C>T polymorphism in VEGF gene region has been implicated in cancer risk and related to VEGF expression. However, published data remain conflicting. To derive a more precise estimation, a meta-analysis of 5,863 cases and 5,276 controls from 14 published case-control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. VEGF -460T represented a risk factor for cancers in Asians (OR=1.69, 95% CI: 1.09-2.62) but not in Europeans (OR=0.92, 95% CI: 0.78-1.08). Our meta-analysis showed the evidence that VEGF -460T was associated with increased cancer risk in Asians. Further prospective researches with larger numbers of worldwide participants are expected to validate this result.

Citing Articles

Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer.

Sunakawa Y, Stremitzer S, Cao S, Zhang W, Yang D, Wakatsuki T Ann Oncol. 2014; 26(2):332-9.

PMID: 25411415 PMC: 4304380. DOI: 10.1093/annonc/mdu542.

Association of VEGF gene polymorphisms with diabetic retinopathy: a meta-analysis.

Gong J, Sun Y PLoS One. 2013; 8(12):e84069.

PMID: 24376787 PMC: 3869859. DOI: 10.1371/journal.pone.0084069.

Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer: a meta-analysis involving 2,444 individuals.

Leng W, He M, Chen Q, Gong H, Zhang L, Zeng X Mol Biol Rep. 2013; 40(10):5987-92.

PMID: 24057180 DOI: 10.1007/s11033-013-2708-y.

Vascular endothelial growth factor (VEGF) -2578C/A and -460C/T gene polymorphisms and lung cancer risk: a meta-analysis involving 11 case-control studies.

Song N, Liu B, Wu J, Zhang R, Duan L, He W Tumour Biol. 2013; 35(1):859-70.

PMID: 23982876 DOI: 10.1007/s13277-013-1119-y.

Polymorphism of VEGF-460C/T associated with the risk and clinical characteristics of lung cancer in Chinese population.

Sun S, Huang D, Cao C, Deng Z Med Oncol. 2013; 30(1):410.

PMID: 23288726 DOI: 10.1007/s12032-012-0410-x.

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