VEGF Gene Polymorphisms and Susceptibility to Colorectal Cancer Disease in Italian Population

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2008 Oct 3

PMID 18830612

Citations 16

Authors

Paolo Maltese

Emanuele Canestrari

Annamaria Ruzzo

Francesco Graziano

Alfredo Falcone

Fotios Loupakis

Giuseppe Tonini

Daniele Santini

Mauro Magnani

Affiliations

Soon will be listed here.

Abstract

Background: The vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in the process of angiogenesis, a crucial phase in tumor growth and metastasis. We carried out a case-control study to evaluate whether polymorphisms of VEGF gene modulate the risk of developing colorectal cancer disease (CCD).

Materials And Methods: We evaluated VEGF -2578A/C, -460T/C, and +405C/G genotypes obtained from a series of 302 CCD patients and 115 controls from the Italian population using polymerase chain reaction restriction fragment length polymorphism assay.

Results: Strong linkage disequilibrium (LD) was detected between -2578A/C and -460T/C (D' = 0.97; CI = 0.93-1) and between -2578A/C and +405C/G (D' = 0.97; CI = 0.98-1) in the case group. Complete LD was detected between -2578A/C and +405C/G and between -460T/C and +405C/G (D' = 1; CI = 0.84-1; CI = 0.82-1, respectively) in the control group. A reduced risk for the disease was associated with -2578C/A and -2578C/C (odds ratio (OR) = 0.34, CI = 0.162-0.676 and OR = 0.38, CI = 0.181-0.775, respectively). A direct association was found for carriers of the VEGF -460C/C polymorphism (OR = 3.55; CI = 1.659-8.469). We identified a protective haplotype -2578A, -460T, and +405G (OR = 0.04; CI = 0.009-0.19) and two different high-risk haplotypes -2578A, -460C, and +405G (OR = 1.90; CI = 1.31-2.27) and -2578C, -460C, and +405C (OR = 9.62; CI = 1.3-70.87).

Conclusions: The present study suggests that the VEGF gene polymorphisms may play a role in the development of colorectal cancer.

Citing Articles

Impact of VEGFA promoter polymorphisms on esophageal cancer risk in North-West Indians: a case-control study.

Guleria K, Kaur S, Mahajan D, Sambyal V, Sudan M, Uppal M Genes Genomics. 2022; 44(8):923-936.

PMID: 35767183 DOI: 10.1007/s13258-022-01269-2.

"Vessels in the Storm": Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer.

Angelucci A, Delle Monache S, Cortellini A, Di Padova M, Ficorella C Int J Mol Sci. 2018; 19(1).

PMID: 29351242 PMC: 5796244. DOI: 10.3390/ijms19010299.

Association between three VEGF polymorphisms and renal cell carcinoma susceptibility: a meta-analysis.

Hou Q, Li M, Huang W, Wei F, Peng J, Lou M Oncotarget. 2017; 8(30):50061-50070.

PMID: 28562357 PMC: 5564828. DOI: 10.18632/oncotarget.17833.

Promoter polymorphisms of the vascular endothelial growth factor gene are associated with metabolic syndrome susceptibility in Koreans.

Kim Y, Hong S Biomed Rep. 2017; 6(5):555-560.

PMID: 28515913 PMC: 5431263. DOI: 10.3892/br.2017.886.

Vascular endothelial growth factor -2578C/A polymorphism and colorectal cancer risk: A meta-analysis.

Wang L, Ji S, Cheng Z J Res Med Sci. 2015; 20(8):811-7.

PMID: 26664430 PMC: 4652316. DOI: 10.4103/1735-1995.168406.

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