Host Genetics Influences on HIV Type-1 Disease

Overview

Journal Antivir Ther

Publisher Sage Publications

Specialties Infectious Diseases
Microbiology

Date 2009 Oct 9

PMID 19812435

Citations 14

Authors

Jacques Fellay

Affiliations

Soon will be listed here.

Abstract

HIV host genetic studies seek to describe as comprehensively as possible the effect of human genetic variation on the individual response to HIV type-1 (HIV-1) infection. Many associations between specific gene variants and HIV-1 disease outcomes have been reported over the past 15 years. Although most of them have yet to be confirmed or have been proven false-positives, the identification of several definitive genotype-phenotype associations has shed new light on HIV-1 pathogenesis. This review discusses these results in the context of the new genome-wide approaches that now make it possible to globally assess the influence of the host genome on HIV-1-related outcomes.

Citing Articles

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen.

Neuner-Jehle N, Zeeb M, Thorball C, Fellay J, Metzner K, Frischknecht P PLoS Pathog. 2024; 20(8):e1012385.

PMID: 39116192 PMC: 11335148. DOI: 10.1371/journal.ppat.1012385.

Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population.

Shevchenko A, Zhernakova D, Malov S, Komissarov A, Kolchanova S, Tamazian G Proc Natl Acad Sci U S A. 2021; 118(47).

PMID: 34782459 PMC: 8672799. DOI: 10.1073/pnas.2107830118.

Large-Scale "OMICS" Studies to Explore the Physiopatholgy of HIV-1 Infection.

Le Clerc S, Limou S, Zagury J Front Genet. 2019; 10:799.

PMID: 31572435 PMC: 6754074. DOI: 10.3389/fgene.2019.00799.

Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.

Tsiara C, Nikolopoulos G, Dimou N, Pantavou K, Bagos P, Mensah B J Genet. 2018; 97(1):235-251.

PMID: 29666343

Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle.

Carignano H, Roldan D, Beribe M, Raschia M, Amadio A, Nani J BMC Genomics. 2018; 19(1):142.

PMID: 29439661 PMC: 5812220. DOI: 10.1186/s12864-018-4523-2.

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