Dopamine Type 2/3 Receptor Availability in the Striatum and Social Status in Human Volunteers

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2009 Oct 9

PMID 19811777

Citations 52

Authors

Diana Martinez

Daria Orlowska

Rajesh Narendran

Mark Slifstein

Fei Liu

Dileep Kumar

Allegra Broft

Ronald Van Heertum

Herbert D Kleber

Affiliations

Soon will be listed here.

Abstract

Background: Previous positron emission tomography (PET) imaging studies in nonhuman primates have shown that striatal dopamine type 2/3 (D(2/3)) receptors correlate with social hierarchy in monkeys and that dominant animals exhibit higher levels of D(2/3) receptor binding. The goal of the present study was to examine this phenomena in human subjects using PET and the radiotracer [(11)C]raclopride.

Methods: Fourteen healthy volunteers were scanned with [(11)C]raclopride to measure D(2/3) receptor binding potential (BP). Social status was assessed using the Barratt Simplified Measure of Social Status. In addition, participants were asked to assess their level of social support using the Multidimensional Scale of Perceived Social Support (MSPSS).

Results: A correlation was seen between social status and dopamine D(2/3) receptors, where volunteers with the higher status had higher values for [(11)C]raclopride BP. A similar correlation was seen with the perceived social support, where higher [(11)C]raclopride BP correlated with higher scores on the MSPSS.

Conclusions: The results of this study support the hypothesis that social status and social support is correlated with D(2/3) receptor binding.

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References

Sokoloff P, Giros B, Martres M, Bouthenet M, Schwartz J . Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature. 1990; 347(6289):146-51. DOI: 10.1038/347146a0. View

Farde L, Gustavsson J, Jonsson E . D2 dopamine receptors and personality traits. Nature. 1997; 385(6617):590. DOI: 10.1038/385590a0. View

Czoty P, Riddick N, Gage H, Sandridge M, Nader S, Garg S . Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys. Neuropsychopharmacology. 2008; 34(3):548-54. DOI: 10.1038/npp.2008.3. View

Martinez D, Slifstein M, Broft A, Mawlawi O, Hwang D, Huang Y . Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. J Cereb Blood Flow Metab. 2003; 23(3):285-300. DOI: 10.1097/01.WCB.0000048520.34839.1A. View

Slifstein M, Laruelle M . Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers. Nucl Med Biol. 2001; 28(5):595-608. DOI: 10.1016/s0969-8051(01)00214-1. View

Morgan D, Grant K, Gage H, Mach R, Kaplan J, Prioleau O . Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci. 2002; 5(2):169-74. DOI: 10.1038/nn798. View

Thanos P, Michaelides M, Umegaki H, Volkow N . D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. Synapse. 2008; 62(7):481-6. PMC: 2659016. DOI: 10.1002/syn.20523. View

Nordstrom A, Olsson H, Halldin C . A PET study of D2 dopamine receptor density at different phases of the menstrual cycle. Psychiatry Res. 1998; 83(1):1-6. DOI: 10.1016/s0925-4927(98)00021-3. View

Tamashiro K, Nguyen M, Sakai R . Social stress: from rodents to primates. Front Neuroendocrinol. 2005; 26(1):27-40. DOI: 10.1016/j.yfrne.2005.03.001. View

10.

Schneier F, Martinez D, Abi-Dargham A, Zea-Ponce Y, Simpson H, Liebowitz M . Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings. Depress Anxiety. 2007; 25(1):1-7. DOI: 10.1002/da.20268. View

11.

Woods R, Mazziotta J, Cherry S . MRI-PET registration with automated algorithm. J Comput Assist Tomogr. 1993; 17(4):536-46. DOI: 10.1097/00004728-199307000-00004. View

12.

Kestler L, Malhotra A, Finch C, Adler C, Breier A . The relation between dopamine D2 receptor density and personality: preliminary evidence from the NEO personality inventory-revised. Neuropsychiatry Neuropsychol Behav Neurol. 2000; 13(1):48-52. View

13.

Grant K, Shively C, Nader M, Ehrenkaufer R, Line S, Morton T . Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography. Synapse. 1998; 29(1):80-3. DOI: 10.1002/(SICI)1098-2396(199805)29:1<80::AID-SYN7>3.0.CO;2-7. View

14.

Volkow N, Fowler J, Wang G . The addicted human brain: insights from imaging studies. J Clin Invest. 2003; 111(10):1444-51. PMC: 155054. DOI: 10.1172/JCI18533. View

15.

Munro C, McCaul M, Wong D, Oswald L, Zhou Y, Brasic J . Sex differences in striatal dopamine release in healthy adults. Biol Psychiatry. 2006; 59(10):966-74. DOI: 10.1016/j.biopsych.2006.01.008. View

16.

Schneier F, Liebowitz M, Abi-Dargham A, Zea-Ponce Y, Lin S, Laruelle M . Low dopamine D(2) receptor binding potential in social phobia. Am J Psychiatry. 2000; 157(3):457-9. DOI: 10.1176/appi.ajp.157.3.457. View

17.

Oakes J, Rossi P . The measurement of SES in health research: current practice and steps toward a new approach. Soc Sci Med. 2003; 56(4):769-84. DOI: 10.1016/s0277-9536(02)00073-4. View

18.

Frankle W . Neuroreceptor imaging studies in schizophrenia. Harv Rev Psychiatry. 2007; 15(5):212-32. DOI: 10.1080/10673220701679812. View

19.

Adler N, Boyce T, Chesney M, Cohen S, Folkman S, Kahn R . Socioeconomic status and health. The challenge of the gradient. Am Psychol. 1994; 49(1):15-24. DOI: 10.1037//0003-066x.49.1.15. View

20.

Mawlawi O, Martinez D, Slifstein M, Broft A, Chatterjee R, Hwang D . Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum. J Cereb Blood Flow Metab. 2001; 21(9):1034-57. DOI: 10.1097/00004647-200109000-00002. View