Glycomics and Disease Markers

Overview

Journal Curr Opin Chem Biol

Publisher Elsevier

Specialty Biochemistry

Date 2009 Sep 25

PMID 19775929

Citations 115

Authors

Hyun Joo An

Scott R Kronewitter

Maria Lorna A De Leoz

Carlito B Lebrilla

Affiliations

Soon will be listed here.

Abstract

Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.

Citing Articles

Nanopore-based glycan sequencing: state of the art and future prospects.

Yao G, Ke W, Xia B, Gao Z Chem Sci. 2024; 15(17):6229-6243.

PMID: 38699252 PMC: 11062086. DOI: 10.1039/d4sc01466a.

Influence of plasma collection tubes on N-glycome in human blood samples.

Zhang Z, Cui X, Zhou N, Zhu L, Zhi Y, Zhang S Pract Lab Med. 2024; 39:e00383.

PMID: 38463195 PMC: 10924059. DOI: 10.1016/j.plabm.2024.e00383.

N-glycosylation in non-invasive and invasive intraductal papillary mucinous neoplasm.

Nieminen H, Nummela P, Satomaa T, Heiskanen A, Hiltunen J, Kaprio T Sci Rep. 2023; 13(1):13191.

PMID: 37580349 PMC: 10425445. DOI: 10.1038/s41598-023-39220-4.

The -Glycosylation of Total Plasma Proteins and IgG in Atrial Fibrillation.

Plavsa B, Szavits-Nossan J, Blivajs A, Rapcan B, Radovani B, Sesto I Biomolecules. 2023; 13(4).

PMID: 37189353 PMC: 10135591. DOI: 10.3390/biom13040605.

Serum N-glycomic profiling may provide potential signatures for surveillance of COVID-19.

Xie Y, Butler M Glycobiology. 2022; 32(10):871-885.

PMID: 35925863 PMC: 9487901. DOI: 10.1093/glycob/cwac051.

References

Cooke C, An H, Kim J, Canfield D, Torres J, Lebrilla C . Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology. 2009; 137(3):1061-71, 1071.e1-8. DOI: 10.1053/j.gastro.2009.04.014. View

Turnbull J, Field R . Emerging glycomics technologies. Nat Chem Biol. 2007; 3(2):74-7. DOI: 10.1038/nchembio0207-74. View

Dennis J, Granovsky M, Warren C . Protein glycosylation in development and disease. Bioessays. 1999; 21(5):412-21. DOI: 10.1002/(SICI)1521-1878(199905)21:5<412::AID-BIES8>3.0.CO;2-5. View

Bereman M, Islam Williams T, Muddiman D . Development of a nanoLC LTQ orbitrap mass spectrometric method for profiling glycans derived from plasma from healthy, benign tumor control, and epithelial ovarian cancer patients. Anal Chem. 2008; 81(3):1130-6. PMC: 3739471. DOI: 10.1021/ac802262w. View

Royle L, Campbell M, Radcliffe C, White D, Harvey D, Abrahams J . HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software. Anal Biochem. 2008; 376(1):1-12. DOI: 10.1016/j.ab.2007.12.012. View

An H, Miyamoto S, Lancaster K, Kirmiz C, Li B, Lam K . Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer. J Proteome Res. 2006; 5(7):1626-35. DOI: 10.1021/pr060010k. View

Bleckmann C, Geyer H, Reinhold V, Lieberoth A, Schachner M, Kleene R . Glycomic analysis of N-linked carbohydrate epitopes from CD24 of mouse brain. J Proteome Res. 2008; 8(2):567-82. DOI: 10.1021/pr800729r. View

Lancaster K, An H, Li B, Lebrilla C . Interrogation of N-Linked oligosaccharides using infrared multiphoton dissociation in FT-ICR mass spectrometry. Anal Chem. 2006; 78(14):4990-7. DOI: 10.1021/ac0600656. View

Norton P, Comunale M, Krakover J, Rodemich L, Pirog N, DAmelio A . N-linked glycosylation of the liver cancer biomarker GP73. J Cell Biochem. 2007; 104(1):136-49. PMC: 4620713. DOI: 10.1002/jcb.21610. View

10.

Tanabe K, Deguchi A, Higashi M, Usuki H, Suzuki Y, Uchimura Y . Outer arm fucosylation of N-glycans increases in sera of hepatocellular carcinoma patients. Biochem Biophys Res Commun. 2008; 374(2):219-25. DOI: 10.1016/j.bbrc.2008.06.124. View

11.

Lebrilla C, An H . The prospects of glycan biomarkers for the diagnosis of diseases. Mol Biosyst. 2008; 5(1):17-20. DOI: 10.1039/b811781k. View

12.

Zhang J, Xie Y, Hedrick J, Lebrilla C . Profiling the morphological distribution of O-linked oligosaccharides. Anal Biochem. 2004; 334(1):20-35. DOI: 10.1016/j.ab.2004.07.012. View

13.

Storr S, Royle L, Chapman C, Abd Hamid U, Robertson J, Murray A . The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient's serum. Glycobiology. 2008; 18(6):456-62. DOI: 10.1093/glycob/cwn022. View

14.

Tabares G, Radcliffe C, Barrabes S, Ramirez M, Aleixandre R, Hoesel W . Different glycan structures in prostate-specific antigen from prostate cancer sera in relation to seminal plasma PSA. Glycobiology. 2005; 16(2):132-45. DOI: 10.1093/glycob/cwj042. View

15.

Miyoshi E, Nakano M . Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. Proteomics. 2008; 8(16):3257-62. DOI: 10.1002/pmic.200800046. View

16.

De Leoz M, An H, Kronewitter S, Kim J, Beecroft S, Vinall R . Glycomic approach for potential biomarkers on prostate cancer: profiling of N-linked glycans in human sera and pRNS cell lines. Dis Markers. 2009; 25(4-5):243-58. PMC: 3827814. DOI: 10.1155/2008/515318. View

17.

Dube D, Bertozzi C . Glycans in cancer and inflammation--potential for therapeutics and diagnostics. Nat Rev Drug Discov. 2005; 4(6):477-88. DOI: 10.1038/nrd1751. View

18.

Ishizuka A, Hashimto Y, Naka R, Kinoshita M, Kakehi K, Seino J . Accumulation of free complex-type N-glycans in MKN7 and MKN45 stomach cancer cells. Biochem J. 2008; 413(2):227-37. DOI: 10.1042/BJ20071562. View

19.

Nakano M, Nakagawa T, Ito T, Kitada T, Hijioka T, Kasahara A . Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: a novel approach for the development of tumor markers. Int J Cancer. 2008; 122(10):2301-9. DOI: 10.1002/ijc.23364. View

20.

Isailovic D, Kurulugama R, Plasencia M, Stokes S, Kyselova Z, Goldman R . Profiling of human serum glycans associated with liver cancer and cirrhosis by IMS-MS. J Proteome Res. 2008; 7(3):1109-17. PMC: 3727278. DOI: 10.1021/pr700702r. View