Otitis Media in a Mouse Model for Down Syndrome

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2009 Sep 22

PMID 19765102

Citations 21

Authors

Fengchan Han

Heping Yu

Jiangping Zhang

Cong Tian

Cecilia Schmidt

Casey Nava

Muriel T Davisson

Qing Y Zheng

Affiliations

Soon will be listed here.

Abstract

The Ts65Dn mouse shares many phenotypic characteristics of human Down syndrome. Here, we report that otitis media, characterized by effusion in the middle ear and hearing loss, was prevalent in Ts65Dn mice. Of the 53 Ts65Dn mice tested, 81.1% had high auditory-evoked brainstem response (ABR) thresholds for at least one of the stimulus frequencies (click, 8 kHz, 16 kHz and 32 kHz), in at least one ear. The ABR thresholds were variable and showed no tendency toward increase with age, from 2 to 7 months of age. Observation of pathology in mice, aged 3-4 months, revealed middle ear effusion in 11 of 15 Ts65Dn mice examined, but only in two of 11 wild-type mice. The effusion in each mouse varied substantially in volume and inflammatory cell content. The middle ear mucosae were generally thickened and goblet cells were distributed with higher density in the epithelium of the middle ear cavity of Ts65Dn mice as compared with those of wild-type controls. Bacteria of pathogenic importance to humans also were identified in the Ts65Dn mice. This is the first report of otitis media in the Ts65Dn mouse as a model characteristic of human Down syndrome.

Citing Articles

Ultrasonic vocalization phenotypes in the Ts65Dn and Dp(16)1Yey mouse models of Down syndrome.

Glass T, Lenell C, Fisher E, Yang Q, Connor N Physiol Behav. 2023; 271:114323.

PMID: 37573959 PMC: 10592033. DOI: 10.1016/j.physbeh.2023.114323.

Hearing impairment in murine model of Down syndrome.

Chen G, Li L, McCall A, Ding D, Xing Z, Yu Y Front Genet. 2022; 13:936128.

PMID: 35991545 PMC: 9385999. DOI: 10.3389/fgene.2022.936128.

Auditory Phenotype and Histopathologic Findings of a Mutant Nlrp3 Expression Mouse Model.

Kim Y, Lee S, Kim M, Park K, Han J, Kim J Front Neurol. 2022; 13:890256.

PMID: 35812087 PMC: 9263128. DOI: 10.3389/fneur.2022.890256.

Rodent Modeling of Alzheimer's Disease in Down Syndrome: and Approaches.

Farrell C, Mumford P, Wiseman F Front Neurosci. 2022; 16:909669.

PMID: 35747206 PMC: 9209729. DOI: 10.3389/fnins.2022.909669.

Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response.

Bao J, Jegede S, Hawks J, Dade B, Guan Q, Middaugh S Front Cell Neurosci. 2022; 16:851500.

PMID: 35356798 PMC: 8959412. DOI: 10.3389/fncel.2022.851500.

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