Development and Cancer: at the Crossroads of Nodal and Notch Signaling

Overview

Journal Cancer Res

Specialty Oncology

Date 2009 Sep 10

PMID 19738053

Citations 49

Authors

Luigi Strizzi

Katharine M Hardy

Elisabeth A Seftor

Fabricio F Costa

Dawn A Kirschmann

Richard E B Seftor

Lynne-Marie Postovit

Mary J C Hendrix

Affiliations

Soon will be listed here.

Abstract

Aggressive tumor cells express a plastic, multipotent phenotype similar to embryonic stem cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways, which seems to contribute to their plastic phenotype. Emerging evidence showing the molecular cross-talk between two major stem cell signaling pathways Nodal and Notch suggests a promising therapeutic strategy that could target aggressive tumor cells on the basis of their unique plasticity, and provide new insights into the mechanisms underlying the re-emergence of developmental signaling pathways during tumor progression.

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References

Kwon C, Han Z, Olson E, Srivastava D . MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A. 2005; 102(52):18986-91. PMC: 1315275. DOI: 10.1073/pnas.0509535102. View

Postovit L, Margaryan N, Seftor E, Kirschmann D, Lipavsky A, Wheaton W . Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci U S A. 2008; 105(11):4329-34. PMC: 2393795. DOI: 10.1073/pnas.0800467105. View

Borggrefe T, Oswald F . The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol Life Sci. 2009; 66(10):1631-46. PMC: 11115614. DOI: 10.1007/s00018-009-8668-7. View

ONeill C, Urs S, Cinelli C, Lincoln A, Nadeau R, Leon R . Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol. 2007; 171(3):1023-36. PMC: 1959488. DOI: 10.2353/ajpath.2007.061029. View

Koch U, Radtke F . Notch and cancer: a double-edged sword. Cell Mol Life Sci. 2007; 64(21):2746-62. PMC: 11136344. DOI: 10.1007/s00018-007-7164-1. View

Mueller D, Rehli M, Bosserhoff A . miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J Invest Dermatol. 2009; 129(7):1740-51. DOI: 10.1038/jid.2008.452. View

Pinnix C, Herlyn M . The many faces of Notch signaling in skin-derived cells. Pigment Cell Res. 2007; 20(6):458-65. DOI: 10.1111/j.1600-0749.2007.00410.x. View

Krebs L, Iwai N, Nonaka S, Welsh I, Lan Y, Jiang R . Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 2003; 17(10):1207-12. PMC: 196059. DOI: 10.1101/gad.1084703. View

Lin S, Chang D, Chang-Lin S, Lin C, Wu D, Chen D . Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA. 2008; 14(10):2115-24. PMC: 2553732. DOI: 10.1261/rna.1162708. View

10.

Tabibzadeh S, Hemmati-Brivanlou A . Lefty at the crossroads of "stemness" and differentiative events. Stem Cells. 2006; 24(9):1998-2006. DOI: 10.1634/stemcells.2006-0075. View

11.

Strizzi L, Postovit L, Margaryan N, Lipavsky A, Gadiot J, Blank C . Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention. Expert Rev Dermatol. 2009; 4(1):67-78. PMC: 2682534. DOI: 10.1586/17469872.4.1.67. View

12.

Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H . Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 2001; 20(13):3427-36. PMC: 125257. DOI: 10.1093/emboj/20.13.3427. View

13.

Bartel D . MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2):215-33. PMC: 3794896. DOI: 10.1016/j.cell.2009.01.002. View

14.

Schier A . Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol. 2003; 19:589-621. DOI: 10.1146/annurev.cellbio.19.041603.094522. View

15.

Choi W, Giraldez A, Schier A . Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science. 2007; 318(5848):271-4. DOI: 10.1126/science.1147535. View

16.

Postovit L, Seftor E, Seftor R, Hendrix M . Targeting Nodal in malignant melanoma cells. Expert Opin Ther Targets. 2007; 11(4):497-505. DOI: 10.1517/14728222.11.4.497. View

17.

Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D . Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res. 2004; 64(21):7787-93. DOI: 10.1158/0008-5472.CAN-04-1446. View

18.

Topczewska J, Postovit L, Margaryan N, Sam A, Hess A, Wheaton W . Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med. 2006; 12(8):925-32. DOI: 10.1038/nm1448. View

19.

Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L . Rational targeting of Notch signaling in cancer. Oncogene. 2008; 27(38):5124-31. DOI: 10.1038/onc.2008.226. View

20.

Nickoloff B, Hendrix M, Pollock P, Trent J, Miele L, Qin J . Notch and NOXA-related pathways in melanoma cells. J Investig Dermatol Symp Proc. 2005; 10(2):95-104. DOI: 10.1111/j.1087-0024.2005.200404.x. View