Ageing-related Chromatin Defects Through Loss of the NURD Complex

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2009 Sep 8

PMID 19734887

Citations 167

Authors

Gianluca Pegoraro

Nard Kubben

Ute Wickert

Heike Gohler

Katrin Hoffmann

Tom Misteli

Affiliations

Soon will be listed here.

Abstract

Physiological and premature ageing are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD chromatin remodelling complex as a key modulator of these ageing-associated chromatin defects. We demonstrate loss of several NURD components during premature and normal ageing and we find an ageing-associated reduction in HDAC1 activity. Silencing of individual NURD subunits recapitulated chromatin defects associated with ageing and we provide evidence that structural chromatin defects precede DNA damage accumulation. These results outline a molecular mechanism for chromatin defects during ageing.

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