Genome-wide Association Identifies the ABO Blood Group As a Major Locus Associated with Serum Levels of Soluble E-selectin

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2009 Sep 5

PMID 19729612

Citations 98

Authors

Andrew D Paterson

Maria F Lopes-Virella

Daryl Waggott

Andrew P Boright

S Mohsen Hosseini

Rickey E Carter

Enqing Shen

Lucia Mirea

Bhupinder Bharaj

Lei Sun

Shelley B Bull

Affiliations

Soon will be listed here.

Abstract

Background: Elevated serum soluble E-selectin levels have been associated with a number of diseases. Although E-selectin levels are heritable, little is known about the specific genetic factors involved. E-selectin levels have been associated with the ABO blood group phenotype.

Methods And Results: We performed a high-resolution genome-wide association study of serum soluble E-selectin levels in 685 white individuals with type 1 diabetes from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study to identify major loci influencing levels. Highly significant evidence for association (P=10(-29)) was observed for rs579459 near the ABO blood group gene, accounting for 19% of the variance in E-selectin levels. Levels of E-selectin were higher in O/O than O/A heterozygotes, which were likewise higher than A/A genotypes. Analysis of subgroups of A alleles reveals heterogeneity in the association, and even after this was accounted for, an intron 1 SNP remained significantly associated. We replicate the ABO association in nondiabetic individuals.

Conclusions: ABO is a major locus for serum soluble E-selectin levels. We excluded population stratification, fine-mapped the association to sub-A alleles, and also document association with additional variation in the ABO region.

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