Transillumination Fluorescence Imaging in Mice Using Biocompatible Upconverting Nanoparticles

Overview

Journal Opt Lett

Specialty Ophthalmology

Date 2009 Sep 3

PMID 19724491

Citations 13

Authors

Claudio Vinegoni

Daniel Razansky

Scott A Hilderbrand

Fangwei Shao

Vasilis Ntziachristos

Ralph Weissleder

Affiliations

Soon will be listed here.

Abstract

We report on a systematic study of upconverting fluorescence signal generation within turbid phantoms and real tissues. An accurate three-point Green's function, describing the forward model of photon propagation, is established and experimentally validated. We further demonstrate, for the first time to our knowledge, autofluorescence-free transillumination imaging of mice that have received biocompatible upconverting nanoparticles. The method holds great promise for artifact-free whole-body visualization of optical molecular probes.

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