SiRNA and ShRNA Screens Advance Key Understanding of Host Factors Required for HIV-1 Replication

Overview

Journal Retrovirology

Publisher Biomed Central

Specialty Microbiology

Date 2009 Aug 29

PMID 19712452

Citations 17

Authors

Kin-Hang Kok

Ting Lei

Dong-Yan Jin

Affiliations

Soon will be listed here.

Abstract

A recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions.

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