Knockdown Screens to Knockout HIV-1

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2008 Nov 6

PMID 18984154

Citations 64

Authors

Stephen P Goff

Affiliations

Soon will be listed here.

Abstract

Three recent screens use siRNAs to identify host genes that are critical for HIV-1 replication. These screens have uncovered hundreds of human genes not previously known to be commandeered by the virus during infection. Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration.

Citing Articles

Reliance of Host-Encoded Regulators of Retromobility on Ty1 Promoter Activity or Architecture.

Salinero A, Emerson S, Cormier T, Yin J, Morse R, Curcio M Front Mol Biosci. 2022; 9:896215.

PMID: 35847981 PMC: 9283973. DOI: 10.3389/fmolb.2022.896215.

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency.

Roling M, Sisakht M, Ne E, Moulos P, Crespo R, Stoszko M mBio. 2021; 12(6):e0298021.

PMID: 34872356 PMC: 8649776. DOI: 10.1128/mBio.02980-21.

Predicting host dependency factors of pathogens in using machine learning.

Aromolaran O, Beder T, Adedeji E, Ajamma Y, Oyelade J, Adebiyi E Comput Struct Biotechnol J. 2021; 19:4581-4592.

PMID: 34471501 PMC: 8385402. DOI: 10.1016/j.csbj.2021.08.010.

Experimental Approaches to Identify Host Factors Important for Influenza Virus.

Schaack G, Mehle A Cold Spring Harb Perspect Med. 2019; 10(12).

PMID: 31871241 PMC: 7706581. DOI: 10.1101/cshperspect.a038521.

Analysis of networks of host proteins in the early time points following HIV transduction.

Csosz E, Toth F, Mahdi M, Tsaprailis G, Emri M, Tozser J BMC Bioinformatics. 2019; 20(1):398.

PMID: 31315557 PMC: 6637640. DOI: 10.1186/s12859-019-2990-3.

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