Distribution of Antibody to Hepatitis A Antigen in a Population of Commerical Plasma Doners

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1977 Aug 1

PMID 197116

Citations 1

Authors

W T Hall

F K MUNDON

D L Madden

D DeSouza

J L Kane

Affiliations

Soon will be listed here.

Abstract

Plasma samples from 245 regular plasma donors for Plasma Alliance, Inc. (Knoxville, Tenn.) were tested for the presence of antibody to hepatitis A antigen. Antibody was detected at an immune adherence hemagglutination titer of 1:10 or greater in 37% (91 of 245) of the donors. A statistically significant difference in the frequency of anti-hepatitis A was found between the 18- to 29-year-old group (30%) and the 30- to 49-year-old group (57%). No significant differences between whites and blacks or males afemales were observed. Eighty percent of the donors were in the age range of 18 to 29 years, whereas 48% of the higher-titered plasmas (1:1,000 or greater) were in the 30 to 49 age group. By preselection of donors, it would be possible to produce an immune serum globulin with a specific anti-hepatitis A titer.

Citing Articles

Serodiagnosis of viral hepatitis A by a modified competitive binding radioimmunoassay for immunoglobulin M anti-hepatitis A virus.

Bradley D, Fields H, McCaustland K, MAYNARD J, DECKER R, Whittington R J Clin Microbiol. 1979; 9(1):120-7.

PMID: 219016 PMC: 272968. DOI: 10.1128/jcm.9.1.120-127.1979.

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