Normal and Cancer-related Functions of the P160 Steroid Receptor Co-activator (SRC) Family

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2009 Aug 25

PMID 19701241

Citations 280

Authors

Jianming Xu

Ray-Chang Wu

Bert W OMalley

Affiliations

Soon will be listed here.

Abstract

The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRCgenes are subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRCs promote breast and prostate cancer cell proliferation and survival, have been identified, as have the specific contributions of individual SRC family members to spontaneous breast and prostate carcinogenesis in genetically manipulated mouse models. These studies have identified new challenges for cancer research and therapy.

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