Mitochondrial (dys)function in Adipocyte (de)differentiation and Systemic Metabolic Alterations

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2009 Aug 25

PMID 19700756

Citations 117

Authors

Aurelia De Pauw

Silvia Tejerina

Martine Raes

Jaap Keijer

Thierry Arnould

Affiliations

Soon will be listed here.

Abstract

In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning and performs metabolic regulatory functions. It is the most flexible tissue in the body, because it is remodeled in size and shape by modifications in adipocyte cell size and/or number, depending on developmental status and energy fluxes. Although numerous reviews have focused on the differentiation program of both brown and white adipocytes as well as on the pathophysiological role of white adipose tissues, the importance of mitochondrial activity in the differentiation or the dedifferentiation programs of adipose cells and in systemic metabolic alterations has not been extensively reviewed previously. Here, we address the crucial role of mitochondrial functions during adipogenesis and in mature adipocytes and discuss the cellular responses of white adipocytes to mitochondrial activity impairment. In addition, we discuss the increase in scientific knowledge regarding mitochondrial functions in the last 10 years and the recent suspicion of mitochondrial dysfunction in several 21st century epidemics (ie, obesity and diabetes), as well as in lipodystrophy found in HIV-treated patients, which can contribute to the development of new therapeutic strategies targeting adipocyte mitochondria.

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References

Feige J, Lagouge M, Canto C, Strehle A, Houten S, Milne J . Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008; 8(5):347-58. DOI: 10.1016/j.cmet.2008.08.017. View

Nettleton J, Katz R . n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc. 2005; 105(3):428-40. DOI: 10.1016/j.jada.2004.11.029. View

Kopecky J, Hodny Z, Rossmeisl M, SYROVY I, Kozak L . Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution. Am J Physiol. 1996; 270(5 Pt 1):E768-75. DOI: 10.1152/ajpendo.1996.270.5.E768. View

Milne J, Lambert P, Schenk S, Carney D, Smith J, Gagne D . Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007; 450(7170):712-6. PMC: 2753457. DOI: 10.1038/nature06261. View

Mansfield K, Guzy R, Pan Y, Young R, Cash T, Schumacker P . Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 2005; 1(6):393-9. PMC: 3141219. DOI: 10.1016/j.cmet.2005.05.003. View

Krauss S, Zhang C, Lowell B . The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol. 2005; 6(3):248-61. DOI: 10.1038/nrm1592. View

Dahlman I, Forsgren M, Sjogren A, Nordstrom E, Kaaman M, Naslund E . Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha. Diabetes. 2006; 55(6):1792-9. DOI: 10.2337/db05-1421. View

Daval M, Diot-Dupuy F, Bazin R, Hainault I, Viollet B, Vaulont S . Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem. 2005; 280(26):25250-7. DOI: 10.1074/jbc.M414222200. View

Keijer J, van Schothorst E . Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components. Curr Opin Lipidol. 2008; 19(1):4-10. DOI: 10.1097/MOL.0b013e3282f39f95. View

10.

Harper M, Dent R, Monemdjou S, Bezaire V, Van Wyck L, Wells G . Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes. 2002; 51(8):2459-66. DOI: 10.2337/diabetes.51.8.2459. View

11.

Rust R, Hsieh T, Millhorn D . Regulation of CREB by moderate hypoxia in PC12 cells. Adv Exp Med Biol. 2000; 475:143-52. DOI: 10.1007/0-306-46825-5_14. View

12.

Boschmann M, Thielecke F . The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr. 2007; 26(4):389S-395S. DOI: 10.1080/07315724.2007.10719627. View

13.

Rossmeisl M, Barbatelli G, Flachs P, Brauner P, Zingaretti M, Marelli M . Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo. Eur J Biochem. 2002; 269(1):19-28. DOI: 10.1046/j.0014-2956.2002.02627.x. View

14.

Cadenas S, Echtay K, Harper J, Jekabsons M, Buckingham J, Grau E . The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem. 2001; 277(4):2773-8. DOI: 10.1074/jbc.M109736200. View

15.

Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D . Acquirement of brown fat cell features by human white adipocytes. J Biol Chem. 2003; 278(35):33370-6. DOI: 10.1074/jbc.M305235200. View

16.

Li P, Zhu Z, Lu Y, Granneman J . Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-alpha. Am J Physiol Endocrinol Metab. 2005; 289(4):E617-26. DOI: 10.1152/ajpendo.00010.2005. View

17.

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F . Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127(6):1109-22. DOI: 10.1016/j.cell.2006.11.013. View

18.

Powelka A, Seth A, Virbasius J, Kiskinis E, Nicoloro S, Guilherme A . Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2005; 116(1):125-36. PMC: 1319222. DOI: 10.1172/JCI26040. View

19.

Yun Z, Maecker H, Johnson R, Giaccia A . Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2002; 2(3):331-41. DOI: 10.1016/s1534-5807(02)00131-4. View

20.

Carriere A, Carmona M, Fernandez Y, Rigoulet M, Wenger R, Penicaud L . Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect. J Biol Chem. 2004; 279(39):40462-9. DOI: 10.1074/jbc.M407258200. View