Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Overview

Journal Ann Thorac Surg

Publisher Elsevier

Specialties General Surgery
Pulmonary Medicine

Date 2009 Aug 25

PMID 19699961

Citations 28

Authors

Aaron M Abarbanell

Arthur C Coffey

John W Fehrenbacher

Daniel J Beckman

Jeremy L Herrmann

Brent Weil

Daniel R Meldrum

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

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