Non-coding RNA Transcripts: Sensors of Neuronal Stress, Modulators of Synaptic Plasticity, and Agents of Change in the Onset of Alzheimer's Disease

Overview

Journal Neurosci Lett

Specialty Neurology

Date 2009 Aug 25

PMID 19699259

Citations 12

Authors

Georges St Laurent 3rd

Mohammad Ali Faghihi

Claes Wahlestedt

Affiliations

Soon will be listed here.

Abstract

Non-protein-coding RNAs (ncRNAs) play critical roles on many levels of cellular information processing and pervasive expression of ncRNAs in the nervous system could help explain brain complexity. NcRNAs are enriched in the central nervous system and are associated with specific neuroanatomical regions. Additionally, several recent publications have revealed an important role for deregulation of ncRNAs in various human neuropathologies, such as Alzheimer's disease, Parkinson's disease and Fragile X mental retardation. Herein, we summarize reports on functional ncRNA molecules involved in cellular stress response, particularly related to Alzheimer's disease. We conclude that ncRNAs have a prominent role in maintaining precise physiological levels of gene products directly implicated in Alzheimer's disease pathology.

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