Effects of Galanin on Monoaminergic Systems and HPA Axis: Potential Mechanisms Underlying the Effects of Galanin on Addiction- and Stress-related Behaviors

Overview

Journal Brain Res

Specialty Neurology

Date 2009 Aug 25

PMID 19699187

Citations 31

Authors

Marina R Picciotto

Christian Brabant

Emily B Einstein

Helen M Kamens

Nichole M Neugebauer

Affiliations

Soon will be listed here.

Abstract

Like a number of neuropeptides, galanin can alter neural activity in brain areas that are important for both stress-related behaviors and responses to drugs of abuse. Accordingly, drugs that target galanin receptors can alter behavioral responses to drugs of abuse and can modulate stress-related behaviors. Stress and drug-related behaviors are interrelated: stress can promote drug-seeking, and drug exposure and withdrawal can increase activity in brain circuits involved in the stress response. We review here what is known about the ability of galanin and galanin receptors to alter neuronal activity, and we discuss potential mechanisms that may underlie the effects of galanin on behaviors involved in responses to stress and addictive drugs. Understanding the mechanisms underlying galanin's effects on neuronal function in brain regions related to stress and addiction may be useful in developing novel therapeutics for the treatment of stress- and addiction-related disorders.

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