Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2016 Apr 30

PMID 27127795

Citations 2

Authors

Zhenwen Zhang

Penghua Fang

Biao He

Lili Guo

Johan Runesson

Ulo Langel

Mingyi Shi

Yan Zhu

Ping Bo

Affiliations

Soon will be listed here.

Abstract

Our previous studies testified the beneficial effect of central galanin on insulin sensitivity of type 2 diabetic rats. The aim of the study was further to investigate whether central M617, a galanin receptor 1 agonist, can benefit insulin sensitivity. The effects of intracerebroventricular administration of M617 on insulin sensitivity and insulin signaling were evaluated in adipose tissues of type 2 diabetic rats. The results showed that central injection of M617 significantly increased plasma adiponectin contents, glucose infusion rates in hyperinsulinemic-euglycemic clamp tests, GLUT4 mRNA expression levels, GLUT4 contents in plasma membranes, and total cell membranes of the adipose cells but reduced the plasma C-reactive protein concentration in nondiabetic and diabetic rats. The ratios of GLUT4 contents were higher in plasma membranes to total cell membranes in both nondiabetic and diabetic M617 groups than each control. In addition, the central administration of M617 enhanced the ratios of pAkt/Akt and pAS160/AS160, but not phosphorylative cAMP response element-binding protein (pCREB)/CREB in the adipose cells of nondiabetic and diabetic rats. These results suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats.

Citing Articles

An assembly of galanin-galanin receptor signaling network.

Gopalakrishnan L, Chatterjee O, Raj C, Pullimamidi D, Advani J, Mahadevan A J Cell Commun Signal. 2020; 15(2):269-275.

PMID: 33136286 PMC: 7990979. DOI: 10.1007/s12079-020-00590-3.

Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats.

Guo L, He B, Fang P, Bo P, Zhang Z J Endocrinol Invest. 2020; 44(3):515-522.

PMID: 32588381 DOI: 10.1007/s40618-020-01336-z.

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