Age-related Differences in the Involvement of the Prefrontal Cortex in Attentional Control

Overview

Journal Brain Cogn

Specialties Neurology
Psychiatry

Date 2009 Aug 25

PMID 19699019

Citations 49

Authors

Ruchika Shaurya Prakash

Kirk I Erickson

Stanley J Colcombe

Jennifer S Kim

Michelle W Voss

Arthur F Kramer

Affiliations

Soon will be listed here.

Abstract

We investigated the relative involvement of cortical regions supporting attentional control in older and younger adults during performance on a modified version of the Stroop task. Participants were exposed to two different types of incongruent trials. One of these, an incongruent-ineligible condition, produces conflict at the non-response level, while the second, an incongruent-eligible condition, produces conflict at both non-response and response levels of information processing. Greater attentional control is needed to perform the incongruent-eligible condition compared to other conditions. We examined the cortical recruitment associated with this task in an event-related functional magnetic resonance imaging paradigm in 25 older and 25 younger adults. Our results indicated that while younger adults demonstrated an increase in the activation of cortical regions responsible for maintaining attentional control in response to increased levels of conflict, such sensitivity and flexibility of the cortical regions to increased attentional control demands was absent in older adults. These results suggest a limitation in older adults' capabilities for flexibly recruiting the attentional network in response to increasing attentional demands.

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References

Digirolamo G, Kramer A, Barad V, Cepeda N, Weissman D, Milham M . General and task-specific frontal lobe recruitment in older adults during executive processes: a fMRI investigation of task-switching. Neuroreport. 2001; 12(9):2065-71. DOI: 10.1097/00001756-200107030-00054. View

Blasi G, Goldberg T, Weickert T, Das S, Kohn P, Zoltick B . Brain regions underlying response inhibition and interference monitoring and suppression. Eur J Neurosci. 2006; 23(6):1658-64. DOI: 10.1111/j.1460-9568.2006.04680.x. View

Woolrich M, Behrens T, Beckmann C, Jenkinson M, Smith S . Multilevel linear modelling for FMRI group analysis using Bayesian inference. Neuroimage. 2004; 21(4):1732-47. DOI: 10.1016/j.neuroimage.2003.12.023. View

Liu X, Banich M, Jacobson B, Tanabe J . Functional dissociation of attentional selection within PFC: response and non-response related aspects of attentional selection as ascertained by fMRI. Cereb Cortex. 2005; 16(6):827-34. DOI: 10.1093/cercor/bhj026. View

Smith S, Zhang Y, Jenkinson M, Chen J, Matthews P, Federico A . Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage. 2002; 17(1):479-89. DOI: 10.1006/nimg.2002.1040. View

Durston S, Davidson M, Thomas K, Worden M, Tottenham N, Martinez A . Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRI. Neuroimage. 2003; 20(4):2135-41. DOI: 10.1016/j.neuroimage.2003.08.004. View

Owen A . The functional organization of working memory processes within human lateral frontal cortex: the contribution of functional neuroimaging. Eur J Neurosci. 1997; 9(7):1329-39. DOI: 10.1111/j.1460-9568.1997.tb01487.x. View

DEsposito M, Zarahn E, Aguirre G, Rypma B . The effect of normal aging on the coupling of neural activity to the bold hemodynamic response. Neuroimage. 1999; 10(1):6-14. DOI: 10.1006/nimg.1999.0444. View

Smith E, Jonides J . Storage and executive processes in the frontal lobes. Science. 1999; 283(5408):1657-61. DOI: 10.1126/science.283.5408.1657. View

10.

Banich M, Milham M, Jacobson B, Webb A, Wszalek T, Cohen N . Attentional selection and the processing of task-irrelevant information: insights from fMRI examinations of the Stroop task. Prog Brain Res. 2001; 134:459-70. DOI: 10.1016/s0079-6123(01)34030-x. View

11.

Kramer A, HUMPHREY D, Larish J, Logan G, Strayer D . Aging and inhibition: beyond a unitary view of inhibitory processing in attention. Psychol Aging. 1994; 9(4):491-512. View

12.

Banich M, Milham M, Atchley R, Cohen N, Webb A, Wszalek T . fMri studies of Stroop tasks reveal unique roles of anterior and posterior brain systems in attentional selection. J Cogn Neurosci. 2001; 12(6):988-1000. DOI: 10.1162/08989290051137521. View

13.

Erickson K, Prakash R, Kim J, Sutton B, Colcombe S, Kramer A . Top-down attentional control in spatially coincident stimuli enhances activity in both task-relevant and task-irrelevant regions of cortex. Behav Brain Res. 2008; 197(1):186-97. PMC: 2845993. DOI: 10.1016/j.bbr.2008.08.028. View

14.

Cabeza R, Nyberg L . Imaging cognition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci. 2000; 12(1):1-47. DOI: 10.1162/08989290051137585. View

15.

Milham M, Banich M, Webb A, Barad V, Cohen N, Wszalek T . The relative involvement of anterior cingulate and prefrontal cortex in attentional control depends on nature of conflict. Brain Res Cogn Brain Res. 2001; 12(3):467-73. DOI: 10.1016/s0926-6410(01)00076-3. View

16.

Dishman R, Berthoud H, Booth F, Cotman C, Edgerton V, Fleshner M . Neurobiology of exercise. Obesity (Silver Spring). 2006; 14(3):345-56. DOI: 10.1038/oby.2006.46. View

17.

Erickson K, Colcombe S, Wadhwa R, Bherer L, Peterson M, Scalf P . Training-induced plasticity in older adults: effects of training on hemispheric asymmetry. Neurobiol Aging. 2006; 28(2):272-83. DOI: 10.1016/j.neurobiolaging.2005.12.012. View

18.

DEsposito M, Aguirre G, Zarahn E, Ballard D, Shin R, Lease J . Functional MRI studies of spatial and nonspatial working memory. Brain Res Cogn Brain Res. 1998; 7(1):1-13. DOI: 10.1016/s0926-6410(98)00004-4. View

19.

Braver T, Cohen J, Nystrom L, Jonides J, Smith E, Noll D . A parametric study of prefrontal cortex involvement in human working memory. Neuroimage. 1997; 5(1):49-62. DOI: 10.1006/nimg.1996.0247. View

20.

Jenkinson M . Fast, automated, N-dimensional phase-unwrapping algorithm. Magn Reson Med. 2003; 49(1):193-7. DOI: 10.1002/mrm.10354. View