Effect of Diet-induced Obesity on Acute Pancreatitis Induced by Administration of Interleukin-12 Plus Interleukin-18 in Mice
Overview
Nutritional Sciences
Physiology
Affiliations
Obesity is associated with increased severity of acute pancreatitis (AP). We recently developed a model of AP induced by administration of interleukin (IL)-12+IL-18, two cytokines that are elevated in patients with AP. In this model, severe AP develops in obese leptin-deficient ob/ob mice compared to lean littermates. In the present report, we evaluated the pancreatic response of diet-induced obesity (DIO) mice to IL-12+IL-18. Body weight loss and adipose tissue necrosis were more severe and prolonged in cytokine-injected DIO compared to lean mice. Edematous AP developed in lean mice, whereas DIO mice developed necrotizing AP. Obese DIO mice developed more severe hypocalcemia, increased liver damage and a heightened acute-phase response compared to lean mice, although leukopenia and thrombocytopenia were of comparable severity in lean and DIO mice. Serum levels of IL-6, IL-10, and IL-22 were significantly higher in DIO compared to lean mice, whereas interferon-gamma and tumor necrosis factor-alpha did not differ between the two groups. In conclusion, obesity induced by high-fat diet is associated with increased disease severity and duration in the model of AP induced by administration of IL-12+IL-18.
Huang Q, Wu Z, Zhang Y, Wu Y, Shi C, Liu Y Turk J Gastroenterol. 2023; 34(4):421-426.
PMID: 36806182 PMC: 10210755. DOI: 10.5152/tjg.2023.22145.
Circulating monocytes in acute pancreatitis.
Liu S, Szatmary P, Lin J, Wang Q, Sutton R, Chen L Front Immunol. 2022; 13:1062849.
PMID: 36578487 PMC: 9791207. DOI: 10.3389/fimmu.2022.1062849.
Zai W, Chen W, Liu H, Ju D Biomedicines. 2021; 9(12).
PMID: 34944732 PMC: 8698419. DOI: 10.3390/biomedicines9121912.
Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox.
Khatua B, El-Kurdi B, Patel K, Rood C, Noel P, Crowell M Sci Adv. 2021; 7(5).
PMID: 33514548 PMC: 7846167. DOI: 10.1126/sciadv.abd6449.
Thomas A, Castellanos K, Mancinelli G, Xia Y, Bauer J, Yazici C Clin Transl Gastroenterol. 2020; 11(5):e00152.
PMID: 32358238 PMC: 7263641. DOI: 10.14309/ctg.0000000000000152.