Actin and Microtubule-based Cytoskeletal Cues Direct Polarized Targeting of Proteins in Neurons

Overview

Journal Sci Signal

Specialties Cell Biology
Physiology
Science

Date 2009 Aug 13

PMID 19671926

Citations 29

Authors

Don B Arnold

Affiliations

Soon will be listed here.

Abstract

Neuronal proteins are transported to either the axon or dendrites through the action of kinesin motors; however, understanding of how cytoskeletal elements steer these cargo-motor complexes to one compartment or the other has remained elusive. Three recent developments-the discovery of an actin-based filter within the axon initial segment, the identification of the pivotal role played by myosin motors in dendritic targeting, and the determination of the properties of a kinesin motor that cause it to prefer axonal to dendritic microtubules-have now provided a structural framework for understanding polarized targeting in neurons.

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