Microfluidic Devices for Measuring Gene Network Dynamics in Single Cells

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2009 Aug 12

PMID 19668248

Citations 112

Authors

Matthew R Bennett

Jeff Hasty

Affiliations

Soon will be listed here.

Abstract

The dynamics governing gene regulation have an important role in determining the phenotype of a cell or organism. From processing extracellular signals to generating internal rhythms, gene networks are central to many time-dependent cellular processes. Recent technological advances now make it possible to track the dynamics of gene networks in single cells under various environmental conditions using microfluidic 'lab-on-a-chip' devices, and researchers are using these new techniques to analyse cellular dynamics and discover regulatory mechanisms. These technologies are expected to yield novel insights and allow the construction of mathematical models that more accurately describe the complex dynamics of gene regulation.

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