The Role of Predictive Modelling in Rationally Re-engineering Biological Systems

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2009 Mar 3

PMID 19252506

Citations 17

Authors

Tie Koide

Wyming Lee Pang

Nitin S Baliga

Affiliations

Soon will be listed here.

Abstract

Technologies to synthesize and transplant a complete genome into a cell have opened limitless potential to redesign organisms for complex, specialized tasks. However, large-scale re-engineering of a biological circuit will require systems-level optimization that will come from a deep understanding of operational relationships among all the constituent parts of a cell. The integrated framework necessary for conducting such complex bioengineering requires the convergence of systems and synthetic biology. Here, we review the status of these rapidly developing interdisciplinary fields of biology and provide a perspective on plausible venues for their merger.

Citing Articles

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