Relationship of Vitamin D and Parathyroid Hormone with Obesity and Body Composition in African Americans

Overview

Journal Clin Endocrinol (Oxf)

Specialty Endocrinology

Date 2009 Aug 7

PMID 19656160

Citations 24

Authors

Anna Liza B Valina-Toth

Zongshan Lai

Wonsuk Yoo

Abdul Abou-Samra

Crystal A Gadegbeku

John M Flack

Affiliations

Soon will be listed here.

Abstract

Background: Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known.

Objective: To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures.

Design: A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial.

Measurements: Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH <or=65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH.

Results: Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0.02), truncal (P = 0.03) and extremity (P = 0.03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0.02). Total fat mass in groups 1-3, respectively, was 30.0, 34.0 and 37.4 kg (P = 0.008); truncal fat mass was 13.4, 15.9 and 17.6 kg (P = 0.006) and extremity fat mass was 15.8, 16.9 and 19.7 kg (P = 0.02). Lean mass did not differ across the three groups.

Conclusions: Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.

Citing Articles

Association of vitamin D levels with anthropometric and adiposity indicators across all age groups: a systematic review of epidemiologic studies.

Abiri B, Valizadeh M, Ahmadi A, Amini S, Nikoohemmat M, Abbaspour F Endocr Connect. 2023; 13(2).

PMID: 38032745 PMC: 10831555. DOI: 10.1530/EC-23-0394.

Vitamin D Status in Patients before Thyroidectomy.

Maciejewska-Markiewicz D, Kochman J, Jakubczyk K, Bargiel P, Szlosser Z, Stachowska E Int J Mol Sci. 2023; 24(4).

PMID: 36834638 PMC: 9963776. DOI: 10.3390/ijms24043228.

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.

Babic Leko M, Pleic N, Gunjaca I, Zemunik T Int J Mol Sci. 2022; 23(1).

PMID: 35008468 PMC: 8744774. DOI: 10.3390/ijms23010044.

Vitamin D regulation of adipogenesis and adipose tissue functions.

Nimitphong H, Park E, Lee M Nutr Res Pract. 2020; 14(6):553-567.

PMID: 33282119 PMC: 7683208. DOI: 10.4162/nrp.2020.14.6.553.

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial.

Brahmbhatt S, Mikhail M, Islam S, Aloia J Nutrients. 2020; 12(3).

PMID: 32213826 PMC: 7146156. DOI: 10.3390/nu12030861.

References

Looker A . Body fat and vitamin D status in black versus white women. J Clin Endocrinol Metab. 2004; 90(2):635-40. DOI: 10.1210/jc.2004-1765. View

Arunabh S, Pollack S, Yeh J, Aloia J . Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab. 2003; 88(1):157-61. DOI: 10.1210/jc.2002-020978. View

Young M, Schwartz G, Wang L, Jamieson D, Whitlatch L, Flanagan J . The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis. 2004; 25(6):967-71. DOI: 10.1093/carcin/bgh082. View

McCarty M, Thomas C . PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses. 2003; 61(5-6):535-42. DOI: 10.1016/s0306-9877(03)00227-5. View

Dawson-Hughes B, Harris S, Finneran S . Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab. 1995; 80(12):3657-61. DOI: 10.1210/jcem.80.12.8530616. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Zittermann A . Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006; 92(1):39-48. DOI: 10.1016/j.pbiomolbio.2006.02.001. View

Bolland M, Grey A, Ames R, Mason B, Horne A, Gamble G . The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. Am J Clin Nutr. 2007; 86(4):959-64. DOI: 10.1093/ajcn/86.4.959. View

Li J, Byrne M, Chang E, Jiang Y, Donkin S, Buhman K . 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol. 2008; 112(1-3):122-6. PMC: 2602794. DOI: 10.1016/j.jsbmb.2008.09.006. View

10.

Liel Y, Ulmer E, Shary J, Hollis B, Bell N . Low circulating vitamin D in obesity. Calcif Tissue Int. 1988; 43(4):199-201. DOI: 10.1007/BF02555135. View

11.

Aloia J, Feuerman M, Yeh J . Reference range for serum parathyroid hormone. Endocr Pract. 2006; 12(2):137-44. PMC: 1482827. DOI: 10.4158/EP.12.2.137. View

12.

Bland R, Zehnder D, Hewison M . Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase along the nephron: new insights into renal vitamin D metabolism. Curr Opin Nephrol Hypertens. 2000; 9(1):17-22. DOI: 10.1097/00041552-200001000-00004. View

13.

Kleerekoper M, Nelson D, Peterson E, Flynn M, Pawluszka A, Jacobsen G . Reference data for bone mass, calciotropic hormones, and biochemical markers of bone remodeling in older (55-75) postmenopausal white and black women. J Bone Miner Res. 1994; 9(8):1267-76. DOI: 10.1002/jbmr.5650090817. View

14.

Nemere I, Safford S, Rohe B, DeSouza M, Farach-Carson M . Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):281-5. DOI: 10.1016/j.jsbmb.2004.03.031. View

15.

Kamycheva E, Sundsfjord J, Jorde R . Serum parathyroid hormone level is associated with body mass index. The 5th Tromsø study. Eur J Endocrinol. 2004; 151(2):167-72. DOI: 10.1530/eje.0.1510167. View

16.

Ainsworth B, Haskell W, Whitt M, Irwin M, Swartz A, Strath S . Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000; 32(9 Suppl):S498-504. DOI: 10.1097/00005768-200009001-00009. View

17.

Bell N, Greene A, Epstein S, Oexmann M, Shaw S, Shary J . Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest. 1985; 76(2):470-3. PMC: 423843. DOI: 10.1172/JCI111995. View

18.

Begum N, SUSSMAN K, Draznin B . Calcium-induced inhibition of phosphoserine phosphatase in insulin target cells is mediated by the phosphorylation and activation of inhibitor 1. J Biol Chem. 1992; 267(9):5959-63. View

19.

Bell N, Godsen R, Henry D, Shary J, Epstein S . The effects of muscle-building exercise on vitamin D and mineral metabolism. J Bone Miner Res. 1988; 3(4):369-73. DOI: 10.1002/jbmr.5650030402. View

20.

Scragg R, Holdaway I, Jackson R, Lim T . Plasma 25-hydroxyvitamin D3 and its relation to physical activity and other heart disease risk factors in the general population. Ann Epidemiol. 1992; 2(5):697-703. DOI: 10.1016/1047-2797(92)90014-h. View