Acute and Chronic Anti-inflammatory Properties of the Stem Bark Aqueous and Methanol Extracts of Sclerocarya Birrea (Anacardiaceae)

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2009 Jul 24

PMID 19626276

Citations 12

Authors

Agathe L Fotio

Theophile Dimo

Telesphore B Nguelefack

Paul D D Dzeufiet

Esther Ngo Lemba

Romeo J Temdie

Florence Ngueguim

Maria L Olleros

Dominique Vesin

Etienne Dongo

Pierre Kamtchouing

Irene Garcia

Affiliations

Soon will be listed here.

Abstract

Sclerocarya birrea is used in folk medicine for the treatment of inflammatory disorders. The effect of the stem bark aqueous and methanol extracts of S. birrea (150 or 300 mg/kg) was evaluated on carrageenan-, histamine- or serotonin-induced paw oedema in rats. The methanol extract of S. birrea (300 mg/kg) being the most active, exhibited a maximum inhibition of 75.45 and 55.31% on carrageenan- and histamine-induced inflammation, respectively. When administered at 300 mg/kg, the methanol extract of S. birrea also exhibited 80.68% inhibition on the 10th day and 54.43% inhibition on the 21st day in formalin- or complete Freund's adjuvant (CFA)-induced paw oedema in rats. GSH level was significantly increased (75.14%), while MAD level was significantly decreased (31.22%) in the liver of CFA rats treated with S. birrea (300 mg/kg). The results suggest that the anti-inflammatory activity of the aqueous and methanol extracts of S. birrea is due to the inhibition of histamine and prostaglandin pathways and to its antioxidant activity.

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