Successful Treatment of Persistent Hyperinsulinemic Hypoglycemia with Nifedipine in an Adult Patient

Overview

Journal Endocr Pract

Specialty Endocrinology

Date 2009 Jul 24

PMID 19625246

Citations 11

Authors

Nina Guseva

David Phillips

John P Mordes

Affiliations

Soon will be listed here.

Abstract

Objective: To describe the successful treatment of severe noninsulinoma hyperinsulinemic hypoglycemia with use of a calcium channel blocking agent in an adult patient who had previously undergone a gastric bypass surgical procedure.

Methods: A 65-year-old woman who had undergone a gastric bypass surgical procedure 26 years earlier was hospitalized because of severe postprandial hypoglycemia. During and after hospitalization, the patient underwent assessment with conventional measurements of glucose, insulin, proinsulin, and C-peptide; toxicologic studies; magnetic resonance imaging studies of the pancreas; and determination of hepatic vein insulin concentrations after selective splanchnic artery calcium infusion.

Results: Metabolic variables were consistent with the diagnosis of hyperinsulinemic hypoglycemia. Magnetic resonance imaging revealed the presence of a side branch intraductal papillary mucinous tumor that had been stable for more than 1 year. The results of the calcium-stimulated insulin release study were consistent with nonlocalized hypersecretion of insulin. A trial of frequent small feedings failed to prevent hypoglycemia. On the basis of reports of successful treatment of childhood nesidioblastosis, the patient was then prescribed nifedipine, 30 mg daily. She has subsequently remained free of symptomatic hypoglycemia for 20 months.

Conclusion: A calcium channel blocking agent may be efficacious and a potential alternative to partial pancreatectomy in cases of noninsulinoma hyperinsulinemic hypoglycemia in adults.

Citing Articles

Refractory Hyperinsulinemic Hypoglycemia as a Complication of Roux-en-Y Gastric Bypass Surgery.

Mazhude T, Zahra T Cureus. 2024; 16(9):e69037.

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Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia.

Dieterle M, Husari A, Prozmann S, Wiethoff H, Stenzinger A, Rohrich M Biomedicines. 2023; 11(6).

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Association Between Serious Hypoglycemia and Calcium-Channel Blockers Used Concomitantly With Insulin Secretagogues.

Nam Y, Brensinger C, Bilker W, Flory J, Leonard C, Hennessy S JAMA Netw Open. 2021; 4(9):e2124443.

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Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017-2018): Congenital hyperinsulinism, insulinoma, non-insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata's disease).

Yamada Y, Kitayama K, Oyachi M, Higuchi S, Kawakita R, Kanamori Y J Diabetes Investig. 2019; 11(3):554-563.

PMID: 31742894 PMC: 7232294. DOI: 10.1111/jdi.13180.

Hypoglycemia After Gastric Bypass Successfully Treated With Calcium Channel Blockers: Two Case Reports.

Ames A, Lago-Hernandez C, Grunvald E J Endocr Soc. 2019; 3(7):1417-1422.

PMID: 31286108 PMC: 6608552. DOI: 10.1210/js.2019-00097.

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