» Articles » PMID: 12003307

Persistent Hyperinsulinemic Hypoglycemia of Infancy--successful Therapy with Nifedipine

Overview
Specialty Pediatrics
Date 2002 May 11
PMID 12003307
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

Recent studies have demonstrated a role for calcium channel blocking agents in the treatment of persistent hyperinsulinemic hypoglycemia of infancy. We report a 30 day old infant with PHHI whom we successfully treated with oral nifedipine alone.

Citing Articles

Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management.

Gyemes M, Rahman S, Kapoor R, Flanagan S, Houghton J, Misra S Rev Endocr Metab Disord. 2020; 21(4):577-597.

PMID: 32185602 PMC: 7560934. DOI: 10.1007/s11154-020-09548-7.


Hyperinsulinaemic hypoglycaemia-an overview of a complex clinical condition.

Kostopoulou E, Shah P Eur J Pediatr. 2019; 178(8):1151-1160.

PMID: 31243576 DOI: 10.1007/s00431-019-03414-8.


Congenital Hyperinsulinism: Diagnosis and Treatment Update.

Demirbilek H, Hussain K J Clin Res Pediatr Endocrinol. 2017; 9(Suppl 2):69-87.

PMID: 29280746 PMC: 5790328. DOI: 10.4274/jcrpe.2017.S007.


Diagnosis and treatment of hyperinsulinaemic hypoglycaemia and its implications for paediatric endocrinology.

Demirbilek H, Rahman S, Buyukyilmaz G, Hussain K Int J Pediatr Endocrinol. 2017; 2017:9.

PMID: 28855921 PMC: 5575922. DOI: 10.1186/s13633-017-0048-8.


A novel mutation of gene in a patient with diazoxide-unresponsive congenital hyperinsulinism.

Park J, Lee H, Park C Korean J Pediatr. 2016; 59(Suppl 1):S116-S120.

PMID: 28018462 PMC: 5177692. DOI: 10.3345/kjp.2016.59.11.S116.


References
1.
Lindley K, Dunne M, Kane C, Shepherd R, Squires P, James R . Ionic control of beta cell function in nesidioblastosis. A possible therapeutic role for calcium channel blockade. Arch Dis Child. 1996; 74(5):373-8. PMC: 1511544. DOI: 10.1136/adc.74.5.373. View

2.
Mahachoklertwattana P, Suprasongsin C, Teeraratkul S, Preeyasombat C . Persistent hyperinsulinemic hypoglycemia of infancy: long-term outcome following subtotal pancreatectomy. J Pediatr Endocrinol Metab. 2000; 13(1):37-44. DOI: 10.1515/jpem.2000.13.1.37. View

3.
Lteif A, Schwenk W . Hypoglycemia in infants and children. Endocrinol Metab Clin North Am. 1999; 28(3):619-46, vii. DOI: 10.1016/s0889-8529(05)70091-8. View

4.
CADE A, Walters M, Puntis J, Arthur R, Stringer M . Pancreatic exocrine and endocrine function after pancreatectomy for persistent hyperinsulinaemic hypoglycaemia of infancy. Arch Dis Child. 1999; 79(5):435-9. PMC: 1717738. DOI: 10.1136/adc.79.5.435. View

5.
Bas F, Darendeliler F, Demirkol D, Bundak R, Saka N, Gunoz H . Successful therapy with calcium channel blocker (nifedipine) in persistent neonatal hyperinsulinemic hypoglycemia of infancy. J Pediatr Endocrinol Metab. 1999; 12(6):873-8. DOI: 10.1515/jpem.1999.12.6.873. View